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White Blood Cell Count as a Predictor of Antibiotic Efficacy in Sepsis: Insights from Comparative Studies of Cefepime and Piperacillin-Tazobactam

MedXY Editorial Team•Oct 9, 2026•Critical Care
antibiotic choicecefepimeMortalityPiperacillin-tazobactamsepsiswhite blood cell count

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This analysis reveals that baseline white blood cell (WBC) count significantly modifies the impact of anti-pseudomonal antibiotic choice on 28-day mortality in sepsis. Notably, patients with a WBC count ≥16 showed improved survival with piperacillin-tazobactam compared to cefepime. These findings emerged consistently across two large clinical datasets, underscoring the potential of WBC as a biomarker for antibiotic selection and predictive enrichment in future trials.

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