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Dual Antiglutamate Therapy in Super-Refractory Status Epilepticus After Cardiac Arrest: Insights from the SUPER-CAT Study and Current Evidence
Cardiologycardiac arrestdual antiglutamate therapy

Dual Antiglutamate Therapy in Super-Refractory Status Epilepticus After Cardiac Arrest: Insights from the SUPER-CAT Study and Current Evidence

By MedXY|Oct 10, 2026

This review synthesizes evidence on dual antiglutamate therapy combining AMPA and NMDA receptor blockade in postanoxic super-refractory status epilepticus, highlighting the SUPER-CAT study’s demonstration of improved seizure resolutio

Serial Ketamine Infusions Show Promise in Treatment-Resistant Bipolar Depression: A Groundbreaking Randomized Trial
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treatment-resistant depression
Ketamine

Serial Ketamine Infusions Show Promise in Treatment-Resistant Bipolar Depression: A Groundbreaking Randomized Trial

By MedXY|Sep 27, 2026

A recent randomized clinical trial reveals that adjunctive intravenous ketamine significantly reduces depressive symptoms in treatment-resistant bipolar depression, with good safety and tolerability compared to midazolam.

Intranasal vs. Subcutaneous Ketamine for Acute Traumatic Pain in the ED: Comparable Efficacy and Safety
Anesthesiologysubcutaneous injectionKetamine

Intranasal vs. Subcutaneous Ketamine for Acute Traumatic Pain in the ED: Comparable Efficacy and Safety

By MedXY|Sep 24, 2026

This randomized clinical trial demonstrates no clinically meaningful difference in pain relief between 20 mg intranasal and subcutaneous ketamine for acute musculoskeletal trauma in the emergency department, with minor adverse events being

Low-Dose Ketamine Reduces Opioid Requirements in Mechanically Ventilated ICU Patients: Insights from a Double-Blind Randomized Trial
AnesthesiologyKetaminemechanical ventilation

Low-Dose Ketamine Reduces Opioid Requirements in Mechanically Ventilated ICU Patients: Insights from a Double-Blind Randomized Trial

By MedXY|Sep 20, 2026

A randomized controlled trial demonstrates that adjunct low-dose ketamine infusion safely decreases opioid use in mechanically ventilated adults without increasing delirium or adverse events, suggesting potential benefits in ICU analgosedat

Decoding Ketamine’s Neurophysiology Under General Anesthesia: Insights for Targeted Therapeutics
AnesthesiologyEEG OscillationsKetamine

Decoding Ketamine’s Neurophysiology Under General Anesthesia: Insights for Targeted Therapeutics

By MedXY|Jun 26, 2026

This study reveals that general anesthesia selectively modulates ketamine-induced EEG changes, preserving beta-gamma oscillations while attenuating theta augmentation, highlighting discrete neurophysiologic components underlying ketamine&#8

Ketamine vs. Etomidate: Does Your Choice of Induction Agent Influence Mortality in the Critically Ill?
Anesthesiologyemergency medicineEtomidate

Ketamine vs. Etomidate: Does Your Choice of Induction Agent Influence Mortality in the Critically Ill?

By MedXY|Dec 18, 2025

This article explores recent evidence comparing ketamine and etomidate for rapid sequence intubation. While new cohort data suggests a mortality benefit for ketamine, meta-analyses of randomized trials show clinical equipoise, highlighting

Ketamine or Etomidate for Tracheal Intubation? Unpacking the RSI Trial Findings on Mortality and Hemodynamics
Anesthesiologycritical careEtomidate

Ketamine or Etomidate for Tracheal Intubation? Unpacking the RSI Trial Findings on Mortality and Hemodynamics

By MedXY|Dec 18, 2025

The large-scale RSI randomized trial found no significant difference in 28-day mortality between ketamine and etomidate for intubating critically ill adults, though ketamine was associated with a higher risk of cardiovascular collapse.

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial
newsKetaminemajor depression

Evaluating Serial Ketamine Infusions as Adjuncts in Inpatient Depression Care: Insights from the KARMA-Dep 2 Trial

By MedXY|Oct 24, 2025

The KARMA-Dep 2 trial reveals that serial ketamine infusions do not significantly outperform midazolam in reducing depressive symptoms among inpatients receiving usual psychiatric care, challenging assumptions about ketamine’s long-term ant

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