Cardiology
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Can a Sirolimus-Eluting Balloon Reduce Stent Use in De Novo Coronary Disease? New Randomized Evidence from SELUTION DeNovo
A large randomized trial found sirolimus-eluting balloon with provisional stenting noninferior to routine DES at 1 year by intention-to-treat analysis, though repeat revascularization was slightly higher and per-protocol noninferiority was
Can a Sirolimus-Eluting Balloon Strategy Rival Routine Stenting in De Novo Coronary Lesions? New Randomized Trial Says Maybe
An SEB plus provisional stenting strategy was noninferior to routine DES at 1 year for target vessel failure, but repeat revascularization was modestly higher and per-protocol noninferiority was not confirmed.
Culture-Negative Infective Endocarditis in the Modern Diagnostic Era: Patient Characteristics and Heterogeneity in a Nationwide Cohort
A nationwide Danish study found that culture-negative infective endocarditis was less common than previously reported, often presented without fever or sepsis, and showed higher embolic risk. PET-CT was especially useful in prosthetic valve
Silent Plaque Ruptures in Non-Obstructive Lesions of Non-Infarct-Related Arteries: What Serial Coronary Imaging Reveals
In patients with acute myocardial infarction, silent plaque rupture was found in 12% of non-obstructive lesions in non-infarct-related arteries. Larger plaques, positive remodeling, and thinner fibrous caps were linked to rupture, and more
Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study
ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.
Sex-Based Patterns and Trends in Transcatheter Aortic Valve Implantation
A nationwide Medicare study found that women made up a declining share of TAVI patients, had more periprocedural complications, but slightly better long-term survival than men. The findings support sex-specific planning and follow-up in aor
Great Debate: Is the New Risk Factor-Weighted Clinical Likelihood Model Useful for Estimating Pre-Test Probability of Obstructive Coronary Artery Disease?
The RF-CL model is a new ESC-recommended tool for estimating the pre-test probability of obstructive CAD in suspected chronic coronary syndromes. It improves risk stratification and may reduce unnecessary testing, though symptom interpretat
Diabetes and Sudden Cardiac Death: Findings from a Danish Nationwide Study
A nationwide Danish study found that type 1 and type 2 diabetes substantially increase sudden cardiac death risk, especially in younger adults, and contribute meaningfully to shortened life expectancy.
Multiarterial Grafting and Survival After Coronary Artery Bypass Grafting: An Instrumental Variable Analysis
In a large Medicare study, multiarterial grafting after CABG looked beneficial in standard analysis, but the advantage disappeared with instrumental variable adjustment, suggesting earlier observational studies may have overestimated surviv
Tricuspid Valve Replacement Outcomes by Baseline Tricuspid Regurgitation Severity: TRISCEND II Trial
TRISCEND II showed that transcatheter tricuspid valve replacement with EVOQUE markedly reduced tricuspid regurgitation and improved clinical outcomes across baseline severity levels, with a stronger signal for benefit in massive or torrenti
Apolipoprotein C-III Inhibition and the Atherosclerosis Paradox: Lessons from the Essence-TIMI 73b Olezarsen Study
The Essence-TIMI 73b trial reveals that despite a 64% reduction in triglycerides and a 72% drop in remnant cholesterol via olezarsen, non-calcified coronary plaque volume remained unchanged over 12 months.
IVUS Guidance Slashes 1-Year Target Vessel Failure in Complex Bifurcation PCI: Insights from DKCRUSH VIII
The DKCRUSH VIII trial demonstrates that IVUS-guided PCI for complex coronary bifurcation lesions significantly reduces 1-year target vessel failure compared to angiography guidance, primarily by ensuring adherence to specific optimization
Long-Term Health Risks Following Postoperative Hypoparathyroidism in Thyroid Cancer Patients
A nationwide cohort study highlights that thyroid cancer patients with permanent hypoparathyroidism face significantly elevated risks of kidney stones, renal failure, and major cardiovascular events, necessitating comprehensive long-term fo
Navigating the AfMR Maze: Expert Consensus and the Future of Mitral Regurgitation Diagnosis
This article examines the debate between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting why the JACC Expert Consensus offers a more robust framework for clinical prognosis and patient classification
Sex-Specific Risk Stratification in Aortic Regurgitation: Moving Beyond One-Size-Fits-All Thresholds
New evidence suggests that current guidelines for aortic regurgitation may overlook sex-specific risks. A recent study proposes lower surgical thresholds for both sexes and distinct volumetric cutoffs (40 mL/m² for women, 45 mL/m² for men)
Redefining Heart Valve Disease: The Battle Over Atrial Functional Mitral Regurgitation Guidelines
This article explores the critical differences between JACC and ESC definitions for Atrial Functional Mitral Regurgitation (AfMR), highlighting how the JACC Consensus provides a more robust prognostic framework for managing this emerging he
Patient Engagement and the Reality of Home Blood Pressure Monitoring: New Research Perspectives
This study examines patient engagement with home blood pressure monitoring (HBPM) in a remote management program, revealing that accessibility and support do not always guarantee high patient compliance.
Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis
This article explores a major international study of 156 acute eosinophilic myocarditis patients, revealing high mortality rates, the diagnostic necessity of endomyocardial biopsy, and the critical survival benefit of early immunosuppressiv
Mechanical Heart Valves in Pregnancy: Navigating the High Risk of Thrombosis and the Biological Valve Advantage
The ESC EORP ROPAC III registry highlights a stark contrast in pregnancy outcomes between mechanical and biological heart valves, revealing that only 54% of women with mechanical valves achieve an uncomplicated live birth, largely due to an
Ethnic Minority Patients with Heart Failure in England Achieve Superior Survival: The Crucial Role of Specialist Care and Medication Adherence
A large-scale analysis of 239,890 patients in England reveals that Black, Asian, and mixed-ethnicity patients hospitalized for heart failure have significantly lower mortality rates than White patients, largely due to better pharmacological