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High-Dose Vitamin C After Cardiac Arrest: Promise Meets a Negative Signal in VITaCCA

High-Dose Vitamin C After Cardiac Arrest: Promise Meets a Negative Signal in VITaCCA

In a multicenter phase 2 trial, early intravenous vitamin C did not improve post-cardiac arrest organ dysfunction and the 10 g dose was associated with worse outcomes, including renal, cardiac, and neurologic signals.

Section: CardiologyJun 20, 2026

When Does an ICP Crisis Really Count? BOOST II Raises Questions About Bedside Detection in Severe TBI

When Does an ICP Crisis Really Count? BOOST II Raises Questions About Bedside Detection in Severe TBI

A post hoc BOOST II analysis found that many bedside-labeled intracranial pressure crises were not confirmed by continuous electronic data, challenging current ICP episode definitions in severe traumatic brain injury.

Section: Critical CareJun 20, 2026

Personalized Automatic Management of Tracheal Cuff Pressure and Subglottic Secretion Drainage to Prevent Pneumonia in Critically Ill Intubated Patients: The MICROINHALO Multicenter Randomized Controlled Trial

Personalized Automatic Management of Tracheal Cuff Pressure and Subglottic Secretion Drainage to Prevent Pneumonia in Critically Ill Intubated Patients: The MICROINHALO Multicenter Randomized Controlled Trial

MICROINHALO found that automatic cuff pressure control plus subglottic secretion drainage did not reduce tracheal colonization, but it was linked to fewer ventilator-associated pneumonia cases in critically ill intubated patients.

Section: Critical CareJun 6, 2026

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.

Section: Critical CareJun 5, 2026

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

Enteral vs IV Magnesium Replacement in Critically Ill Patients: A Randomized Noninferiority Trial

A randomized ICU trial found oral/enteral magnesium was not proven noninferior to IV replacement for correcting mild-to-moderate hypomagnesemia, but it lowered urinary magnesium loss, cost, waste, carbon emissions, and IV fluid use.

Section: Critical CareJun 5, 2026

Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest

Extracorporeal Cardiopulmonary Resuscitation for Pediatric Out-of-Hospital Cardiac Arrest

In selected children with out-of-hospital cardiac arrest, extracorporeal CPR was associated with higher one-month survival and better neurologic outcomes than continued conventional CPR, though the study was observational and estimates were

Section: CardiologyJun 3, 2026

Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure

Four Oxygenation Trajectories Define Reproducible Clinical Archetypes in Persistent Acute Respiratory Failure

A multi-cohort study identified four reproducible 14-day oxygenation trajectory classes in persistent acute hypoxemic respiratory failure, with distinct mortality, biomarker patterns, and links to ARDS and hyperinflammatory subphenotypes.

Section: Critical CareMay 31, 2026

$New SCCM–ESICM Consensus Defines Refractory Septic Shock$

New SCCM–ESICM Consensus Defines Refractory Septic Shock

A new SCCM–ESICM Delphi consensus standardizes clinical criteria for refractory septic shock, focusing on persistent hypoperfusion, fluid unresponsiveness, high vasopressor needs, and bedside ultrasound when mixed shock is suspected.

Section: Critical CareMay 15, 2026

Early Resistance Training and Verticalization During ECMO: A Safe Path to Improved Functional Outcomes

Early Resistance Training and Verticalization During ECMO: A Safe Path to Improved Functional Outcomes

A structured exercise program combining mobility therapy and resistance training in ECMO patients proved feasible and safe, with longer session times correlating with better functional performance.

Section: CardiologyApr 28, 2026

Low-Calorie, Low-Protein Feeding in Shock: No Harm to Kidneys, NUTRIREA-3 Analysis Confirms

Low-Calorie, Low-Protein Feeding in Shock: No Harm to Kidneys, NUTRIREA-3 Analysis Confirms

Early low-calorie and low-protein nutrition in critically ill patients with shock does not worsen renal outcomes compared to standard feeding, per NUTRIREA-3 post hoc analysis.

Section: Critical CareApr 22, 2026

Language Barriers and Delirium Detection: Study Reveals Critical Disparities in ICU Care for Spanish-Speaking Patients

Language Barriers and Delirium Detection: Study Reveals Critical Disparities in ICU Care for Spanish-Speaking Patients

A new study highlights significant disparities in delirium detection for Spanish-speaking ICU patients, with usual-care methods missing 72% of cases. Caregiver-administered tools improved detection by 47%, offering a potential solution to l

Section: Critical CareApr 24, 2026

Remimazolam Besylate Matches Propofol for Short-Term ICU Sedation: The SHOSREB Trial

Remimazolam Besylate Matches Propofol for Short-Term ICU Sedation: The SHOSREB Trial

The SHOSREB trial demonstrates that remimazolam besylate is non-inferior to propofol for short-term light sedation in mechanically ventilated ICU patients, with both agents achieving 97.5% successful sedation rates and comparable time withi

Section: AnesthesiologyApr 13, 2026

Optimizing Positive End-Expiratory Pressure in Patients Without ARDS: From Non-Inferiority to Bayesian Probabilities of Benefit

Optimizing Positive End-Expiratory Pressure in Patients Without ARDS: From Non-Inferiority to Bayesian Probabilities of Benefit

Bayesian re-analysis of the RELAx trial suggests a 75-78% probability that a lower PEEP strategy is superior to higher PEEP in ICU patients without ARDS, with even higher benefits observed in specific clinical subgroups.

Section: Clinical UpdatesApr 6, 2026

Red Blood Cell Exchange Transfusion for Severe Babesiosis: Evidence for Improved Survival and Clinical Outcomes

Red Blood Cell Exchange Transfusion for Severe Babesiosis: Evidence for Improved Survival and Clinical Outcomes

Recent multicenter data indicates that red blood cell exchange transfusion (ET) provides a nearly five-fold reduction in mortality and readmission for patients with severe babesiosis, challenging earlier smaller-scale observations.

Section: Clinical UpdatesApr 6, 2026

Mind the Gap: Why Point-of-Care and Central Lab Electrolytes Are Not Interchangeable in the ICU

Mind the Gap: Why Point-of-Care and Central Lab Electrolytes Are Not Interchangeable in the ICU

A prospective study highlights significant discrepancies between point-of-care and central laboratory sodium and potassium measurements in the ICU, revealing a 10.48 mmol/L limit of agreement for sodium and a widespread lack of physician aw

Section: Critical CareMar 29, 2026

Rethinking Shock Management: From Standardized Protocols to Personalized Precision Medicine

Rethinking Shock Management: From Standardized Protocols to Personalized Precision Medicine

Expert consensus highlights a shift in shock treatment, emphasizing that standardized protocols must give way to personalized, physiology-driven bedside care to prevent iatrogenic injury and improve survival.

Section: Critical CareMar 20, 2026

Electrolyte Monitoring in the ICU: Bridging the Gap Between Point-of-Care and Central Laboratory Discrepancies

Electrolyte Monitoring in the ICU: Bridging the Gap Between Point-of-Care and Central Laboratory Discrepancies

This review analyzes the analytical biases between direct and indirect potentiometry for sodium and potassium measurement in critical care, highlighting significant clinical classification discrepancies and a widespread lack of physician aw

Section: Clinical UpdatesMar 18, 2026

Antipsychotic Exposure in the ICU: A Double-Edged Sword for Catatonia Risk?

Antipsychotic Exposure in the ICU: A Double-Edged Sword for Catatonia Risk?

A prospective cohort study demonstrates that antipsychotic use in critically ill patients is significantly associated with fewer catatonia-free days, suggesting that dopamine blockade may be a primary driver of catatonic syndromes in intens

Section: Critical CareMar 14, 2026

Daily Chlorhexidine Bathing in the ICU: Results from the CLEAN-IT Multicentre Trial

Daily Chlorhexidine Bathing in the ICU: Results from the CLEAN-IT Multicentre Trial

A large-scale trial in Brazilian ICUs found that daily chlorhexidine bathing did not lower overall nosocomial infection rates but significantly reduced multi-drug resistant pathogen isolation and the use of high-priority reserve antibiotics

Section: Critical CareMar 3, 2026

Albumin Replacement in Septic Shock: Safety Confirmed but Survival Benefit Remains Elusive

Albumin Replacement in Septic Shock: Safety Confirmed but Survival Benefit Remains Elusive

The ARISS randomized clinical trial found that 20% albumin supplementation to maintain serum levels ≥3.0 g/dL is safe in septic shock but does not significantly improve 90-day survival compared to standard crystalloids, though the study’s e

Section: Critical CareFeb 24, 2026

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