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Kidney Replacement Therapy Independently Predicts 90-Day Mortality in Critically Ill Patients with Obesity: A 15-Year Trend Analysis

A 15-year cohort study reveals that obese ICU patients requiring kidney replacement therapy face nearly triple the mortality rate of those who do not, despite a declining trend in overall acute kidney injury incidence within this high-risk

Section: Critical CareDec 31, 2025

Beyond Chronological Age: How Frailty Dictates Survival and Functional Recovery After Out-of-Hospital Cardiac Arrest

A secondary analysis of the TTM2 trial reveals that frailty is a potent predictor of mortality and poor neurological outcomes after out-of-hospital cardiac arrest, with severely frail patients facing a 35-fold higher risk of poor functional

critical care

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Kidney Replacement Therapy Independently Predicts 90-Day Mortality in Critically Ill Patients with Obesity: A 15-Year Trend Analysis

Beyond Chronological Age: How Frailty Dictates Survival and Functional Recovery After Out-of-Hospital Cardiac Arrest

Norepinephrine at Extubation: Challenging the Hemodynamic Safety Paradigm in Critically Ill Patients with Obesity

Hemodynamic vs. Neurological Phenotypes in Adult Invasive Meningococcal Disease: Insights from the Nationwide RETRO-MENINGO Study

Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis

Melatonin in the ICU Does Not Translate to Reduced Delirium Incidence

Precision Dosing in the ICU: Extended Infusions of Meropenem and Piperacillin Optimize Therapy During Renal Replacement

Inflammatory Subphenotypes in COVID-19 ARDS Exhibit High Temporal Stability: Insights from the ICAR Trial

Beyond a Marker of Severity: Reaffirming the Impact of Ventilator-Associated Events on Mortality

Higher Blood Pressure Targets in Septic Shock: When More Vasopressors Do More Harm than Good

Survival in Cancer Patients with ARDS: The YELENNA Study Challenges ECMO Utility in Severe Cases

Sepsis Survival in Australia and New Zealand: Analyzing Two Decades of Progress and the Recent Mortality Rebound

Navigating the Long Road: Prolonged Ventilator Weaning and High Reintubation Risk in GBS and Myasthenia Gravis

The Long Shadow of the ICU: Identifying High-Risk Functional Trajectories in Older Survivors

Precision Rehabilitation: Machine Learning Reveals Why ‘Early Mobilization’ Fails Some ICU Patients While Saving Others

Safe Stewardship: Antibiotic De-escalation by Day 4 Reduces Hospitalization Length Without Increasing Mortality in Community-Onset Sepsis

Rising Hospital Mortality and Escalating Rates of Life-Sustaining Therapy Withdrawal in Critically Ill TBI Patients: A 15-Year Analysis

Ketamine or Etomidate for Tracheal Intubation? Unpacking the RSI Trial Findings on Mortality and Hemodynamics

High-frequency Oscillatory Ventilation in Near‑Term and Term Infants: Inconclusive Benefit and Possible Increased Mortality — What the 2025 Cochrane Update Tells Clinicians

Bridging the Gap: Improving Agreement Between Nurse-Documented ICDSC and Researcher CAM-ICU Delirium Assessments in the ICU