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This review synthesizes evidence from the PROOF-HD placebo arm and related studies, demonstrating that antidopaminergic medication use in Huntington disease correlates with accelerated decline in functional, motor, and cognitive outcomes, e
This study compares contact lens-associated and non-contact lens-associated fungal keratitis, highlighting earlier presentation and better medical therapy outcomes in contact lens users versus a more complicated course in non-users.
Quadriceps strength recovery after ACL reconstruction exhibits three distinct trajectories linked to preoperative strength and meniscectomy status, yet these trajectories do not correlate with postoperative clinical outcomes at one year.
This article explores how baseline aldosterone concentrations influence the efficacy and outcomes of mineralocorticoid receptor antagonists (MRAs) in heart failure patients, highlighting the need for tailored therapeutic approaches.
A validated set of 17 quality indicators (QIs) for lupus nephritis, derived from the 2025 EULAR recommendations, shows variable adherence in practice and an association between higher adherence and lower damage accrual in a tertiary-care co
This pooled analysis of INTERACT and ATACH-II trials reveals that intensive blood pressure lowering significantly improves outcomes only in patients with deep intracerebral hemorrhage, highlighting hematoma location as crucial for personali
This study investigates how dose reductions and discontinuations of antifibrotic therapies influence disease progression in idiopathic pulmonary fibrosis (IPF), revealing significant challenges in drug tolerability and the need for improved
This study evaluates the data quality, variability, and clinical outcomes of inpatient social determinants of health screening across 18 hospitals, revealing important disparities and validating the screening tool’s clinical relevance
This review synthesizes current evidence on hemoglobin thresholds in heart failure, highlighting that optimal prognosis is associated with hemoglobin levels higher than WHO anemia cutoffs, with clinical implications for management and iron
This article reviews improvements in heart failure management and outcomes in Japan between 2013 and 2019-21, highlighting increased guideline-based therapy use and enhanced post-discharge care leading to reduced mortality and readmission r
Autoimmune conditions in acute interstitial pneumonia (AIP) are associated with reduced 90-day mortality and better discharge outcomes, indicating distinct clinical trajectories and opportunities for tailored care.
This review synthesizes evidence linking NOAC use to slower cognitive decline and improved clinical outcomes in patients with atrial fibrillation and Alzheimer’s disease, highlighting advantages over warfarin and non-use.
Anti-PD-1 therapy has transformed classical Hodgkin lymphoma management, demonstrating safety, feasibility, and durable efficacy across treatment settings—from relapsed/refractory disease to frontline therapy.
This report highlights the increased risk of health insurance instability in survivors of firearm injury, emphasizing the challenges to continuous care and financial burden post-injury.
This study elucidates how baseline perfusion imaging parameters impact clinical outcomes and safety in isolated posterior cerebral artery occlusions treated with endovascular therapy, highlighting prognostic significance but limited predict
The DigiSep trial assessed the impact of metagenomic next-generation sequencing (mNGS) on sepsis outcomes. While primary endpoint improvement was not significant, secondary analyses revealed benefits in mechanical ventilation duration, shoc
The FOREST-HCM long-term study confirms aficamten’s efficacy and safety in reducing left ventricular outflow tract obstruction and improving symptoms in obstructive hypertrophic cardiomyopathy over nearly one year of treatment.
This review synthesizes findings from a large-scale cohort study comparing laparoscopic and abdominal hysterectomy, highlighting significant surgical advantages for laparoscopy despite complex survival data.
This review synthesizes evidence on sex differences in syncope management, highlighting that while men face higher admission rates and adverse events, these disparities are largely driven by baseline clinical risk factors rather than gender
A large-scale retrospective study reveals that while previous abdominal surgeries do not compromise weight loss after bariatric procedures, they significantly increase intraoperative complexity, operative time, and the risk of postoperative
