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A prospective study reveals that patients with mental health conditions face significant delays in STEMI diagnosis, resulting in larger infarct sizes and a twofold increase in five-year cardiovascular mortality compared to those without suc
A large-scale study of US veterans demonstrates that oral magnesium therapy significantly improves outcomes in heart failure patients with hypomagnesemia, especially those with levels below 1.3 mg/dL. Conversely, supplementation in normomag
The multicentre OCCUPI trial showed OCT-guided PCI reduced 1‑year major adverse cardiac events versus angiography (HR 0.62). A prespecified OCT subanalysis found that achieving predefined OCT optimization (expansion, apposition, no major ed
In the OCCUPI trial, achievement of predefined OCT optimization criteria after OCT‑guided PCI for complex coronary lesions was associated with a large reduction in 1‑year major cardiac events versus sub‑optimized cases and angiography guida
The ALIGN-AR studies demonstrate that transcatheter aortic valve implantation using the Trilogy valve is a safe and effective treatment for symptomatic native moderate-to-severe or severe aortic regurgitation in patients at high surgical ri
Continued oral anticoagulant therapy after ≥90 days for unprovoked VTE significantly lowers recurrence and mortality despite increased bleeding risk, offering a net clinical benefit consistent across anticoagulant types and treatment durati
Hypertension independently worsens clinical outcomes and liver fibrosis progression in MASLD, highlighting the need for integrated cardiovascular and hepatic care.
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
In primary biliary cholangitis (PBC) patients treated with obeticholic acid (OCA), biochemical non-response strongly predicts a higher risk of clinical events including liver decompensation and mortality, underscoring the need for improved
The MITRACURE registry reveals late-stage referral and suboptimal early intervention in mitral regurgitation surgery, highlighting the need for improved management strategies to enhance repair rates and reduce mortality.
The MITRACURE international registry reveals that mitral valve surgery patients often present late in disease progression with advanced symptoms, showing modest repair rates and notable in-hospital mortality, underscoring the need for earli
This international multicenter study evaluates total neoadjuvant therapy (TNT) in routine clinical practice for stage II/III rectal adenocarcinoma, demonstrating varied regimen use and confirming TNT’s efficacy across treatment strategies.
Underexpansion of the ACURATE neo2 valve during TAVR is linked to increased risk of death, stroke, and rehospitalization at one year, suggesting that achieving optimal valve expansion may improve patient outcomes.
This prespecified analysis of the MINT trial evaluates how liberal versus restrictive red blood cell transfusion strategies affect 30-day outcomes in acute MI patients, focusing on those undergoing revascularization, revealing nuanced risk
Low-dose carperitide shows no significant benefit on long-term outcomes in acute heart failure, with evidence from randomized and large-scale cohort studies suggesting possible increased short-term risks compared to nitrates.
Mayo Clinic leads U.S. News’ 2025-2026 rankings for gastroenterology and GI surgery, reflecting excellence in outcomes, capabilities, and research. This review examines the clinical context, ranking methodology, and relevance for clin
Massachusetts General Hospital leads the 2025-2026 US News psychiatric hospital rankings. Rankings highlight excellence in psychiatric care, but methodological nuances and clinical implications warrant closer examination.