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CRISPR-engineered GGTA1/B4GALNT2/SLA-DR knockout pigs remained healthy, screened negative for 55 zoonotic pathogens, and supported long-term renal xenograft function in rhesus monkeys when preformed anti-SLA antibodies were absent.
Machine learning identified two distinct bilateral hepatocellular carcinoma phenotypes with different tumor burdens, surgical approaches, and outcomes, suggesting preoperative risk stratification may improve patient selection and treatment
This review synthesizes findings from the Bridge to HOPE multicenter trial and other recent evidence, demonstrating that portal-venous hypothermic oxygenated perfusion (HOPE) significantly reduces early allograft dysfunction, improves bilia
In complex redo and giant hiatal hernia repair, lateral diaphragmatic relaxing incisions were feasible and associated with favorable patient-reported symptom control at 24 months, although objective recurrence data are still lacking.
A modified diaphragmatic relaxing incision technique may reduce tension during difficult redo and giant hiatal hernia repairs, with most patients reporting improved reflux symptoms and low postoperative symptom burden.
A nationwide Danish cohort found lower risks of reoperation for recurrence and bowel obstruction after onlay mesh placement compared with retromuscular repair and IPOM in elective primary ventral hernia repair.
The American Thyroid Association’s updated consensus refines who can safely undergo outpatient thyroid surgery and what teams must do before, during, and after the operation to reduce complications.
In a 12-hospital Dutch registry, surgical myectomy effectively relieved LVOT obstruction, but 30-day complications were more frequent in low-volume centers, in women, and when at least two concomitant procedures were performed.
In a large single-center cohort, Graves’ disease patients with preoperative TSH ≥10.0 μIU/mL had greater blood loss, larger preoperative thyroid enlargement, and longer operations, suggesting that avoiding iatrogenic hypothyroidism during s
In OPINION, prophylactic left atrial appendage occlusion during valve surgery did not significantly lower stroke, TIA, or cardiovascular death at 1 year in patients without pre-operative atrial fibrillation.
Wearable activity tracking in the DIPLOMA-2 trial found that minimally invasive pancreatoduodenectomy led to more activity for about 5 weeks and less physiologic stress up to 90 days versus open surgery.
In the SANO cohort, 85% of patients with uncertain post-chemoradiotherapy response had residual tumor at esophagectomy, supporting surgery for most, while highlighting a notable complete response subgroup among squamous cell carcinoma with
A 20-year single-center experience suggests frozen elephant trunk plus total arch replacement offers durable survival and fewer late adverse aortic events than hemiarch repair in acute type A aortic dissection.
In a stepped-wedge trial across 18 US centers, a pediatric GI surgery enhanced recovery protocol did not improve length of stay overall, but patients receiving at least 13 protocol elements had shorter stays, fewer complications, faster die
ABRUPT2 found that adding 5% albumin to lactated Ringer’s significantly reduced fluid needs in the first 48 hours after major burns, without clear differences in mortality, kidney injury, or healing time.
A qualitative study found that fatigue after thyroidectomy is common, disruptive, and often unexpected. Patients described major impacts on work and daily life, and many wanted surgeons to warn them about it before surgery.
A national database study found that neoadjuvant chemotherapy was linked to worse overall survival than upfront surgery in node-positive hormone receptor-positive, HER2-negative breast cancer, except in patients who achieved nodal complete
In occult breast cancer, clipped-node pathology after neoadjuvant therapy tracked residual axillary disease with high specificity, supporting limited axillary surgery in selected patients, especially those with cN1–cN2 disease.
Three-year LIFE-BTK data show sustained patency and reintervention benefits with a drug-eluting resorbable scaffold versus angioplasty in selected patients with infrapopliteal CLTI, with comparable limb salvage and safety.
A 2026 cross-sectional study suggests that routine postdissection vagal stimulation during thyroidectomy detects recurrent laryngeal nerve dysfunction more sensitively than RLN stimulation alone and may reduce the risk of bilateral vocal co
