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The PREOPANC-2 trial compared neoadjuvant FOLFIRINOX and gemcitabine-based chemoradiotherapy in resectable and borderline resectable pancreatic cancer, finding no significant overall survival difference between the two regimens.
A Danish cohort study identifies that using mesh weighing 45-65 g/m² in laparoscopic inguinal hernia repair results in the lowest reoperation rate for recurrence, guiding surgical mesh selection for better patient outcomes.
The PRETREAT trial found that proactive blood pressure management tailored by risk of intraoperative hypotension does not reduce postoperative functional disability compared to standard care in noncardiac surgery.
This Cochrane review update evaluates duct-to-mucosa pancreaticojejunostomy compared to other anastomotic techniques following pancreaticoduodenectomy for preventing postoperative pancreatic fistula, finding very low-certainty evidence and
Four RCTs comparing robotic and laparoscopic Nissen fundoplication for GERD show equivalent patient outcomes but longer operative times and higher costs with robotics, questioning its routine use.
A randomized clinical trial demonstrates that placing synthetic mesh during stoma reversal virtually eliminates stomal site incisional hernias and improves hernia-related quality of life without increasing complications.
This review synthesizes evidence comparing postoperative pulmonary complications (PPCs) between robot-assisted surgery (RAS) and conventional laparoscopic surgery (CLS) in abdominal procedures, highlighting the pivotal role of ventilation d
Pragmatic clinical trials offer innovative solutions to overcome unique challenges in surgical research, enhancing evidence quality and applicability by integrating flexible, routine-care-based trial designs and leveraging real-world data.
A 6-week multimodal prehabilitation program combining exercise and nutrition significantly reduces postoperative morbidity in sarcopenic patients undergoing major liver resection, highlighting a promising strategy to improve surgical outcom
A large US cohort study reveals that 14% of bariatric surgery patients start GLP-1 receptor agonists postoperatively, with higher use seen among women, sleeve gastrectomy recipients, and those with greater BMI regain.
A decade-long Medicare study shows low overall risk of mesh removal from infection after open ventral hernia repair, with a slightly higher risk in patients experiencing early wound complications.
The BIOLAP trial demonstrates that biological meshes do not reduce postoperative pain in laparoendoscopic inguinal hernia repair and are associated with higher recurrence and seroma rates compared to synthetic meshes, underscoring synthetic
The DIPLOMA trial demonstrates that minimally invasive left pancreatectomy for resectable pancreatic cancer offers comparable long-term survival outcomes to open surgery, validating its oncologic safety and supporting its use in clinical pr
A rigorous pooled analysis of over 35,000 patients identifies a recurrence risk below 0.5% at 6 years post-surgery, providing a practical benchmark for defining cure in stage II-III colon cancer and refining patient management strategies.
This study evaluates how reported β-lactam allergy and choice of prophylactic antibiotics impact surgical site infection rates, revealing non-β-lactam use increases SSI risk while allergy alone does not independently predict infections.
The INSPIRE 3 and 4 trials demonstrate that computerized provider order entry (CPOE) prompts with patient-specific MDRO risk estimates, combined with education and feedback, significantly reduce empiric extended-spectrum antibiotic use in s
This analysis reveals pervasive underreporting of clinical relevance thresholds in studies comparing open, laparoscopic, and robotic inguinal hernia repairs, urging a shift beyond p-values to improve evidence-based surgical decisions.
Elevated plasma TMAO levels are associated with higher risk of abdominal aortic aneurysm development, rapid aneurysm growth, and need for surgical repair, providing a promising tool for risk stratification and personalized surveillance.
A double-blind, placebo-controlled trial demonstrates that shunt surgery significantly improves gait velocity and balance in patients with idiopathic normal-pressure hydrocephalus who respond to temporary CSF drainage, with mixed safety out
The MIND trial compared minimally invasive surgery using the Artemis device to standard medical management for supratentorial intracerebral hemorrhage, finding no significant improvement in 180-day functional outcomes or 30-day mortality wi
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