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Recent research confirms that antibiotic exposure doubles the risk of hospital-onset Clostridioides difficile infection (CDI), especially in non-carriers, underscoring the central role of antibiotic stewardship and the need for additional p
Elevated CRP levels independently predict short-term mortality in acute myocardial infarction complicated by cardiogenic shock, with extracorporeal life support showing no survival benefit regardless of CRP levels or admission timing.
A recent double-blind RCT shows iloprost did not reduce organ failure severity in septic shock patients with persistent hypoperfusion, highlighting challenges in improving outcomes despite theoretical benefits in microcirculation.
A randomized trial evaluating Normosol-R versus lactated Ringers in critically ill adults found no significant difference in acid-base balance, kidney replacement therapy rates, or 30-day mortality, supporting comparable efficacy between th
The UK-ROX randomized trial (n=16,500) found that targeting SpO2 90% (88–92%) to reduce oxygen exposure did not reduce 90‑day all‑cause mortality versus usual care in mechanically ventilated adults.
This trial demonstrates that a ketogenic diet safely induces stable ketosis in sepsis patients, improving metabolic parameters and immune regulation without adverse effects, suggesting potential benefits for sepsis-related organ dysfunction
A randomized trial assessing the impact of Nurse-Family Partnership home visits on child health and utilization over two years found no significant reduction in adverse outcomes but some decrease in emergency department use.
Severe allergic reaction refers to a sudden, severe, potentially life-threatening systemic allergic reaction in the…
A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.
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