Section
This economic evaluation from the CYCLE randomized trial found no significant cost or quality-adjusted life-year benefit by adding early in-bed cycling to usual physiotherapy for ICU patients on mechanical ventilation, underscoring a need f
A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.
A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.
An international study reveals that postoperative vasopressor infusions after noncardiac surgery vary widely across hospitals and are linked to higher mortality and complications, highlighting the need for optimized management strategies.
A large Canadian prospective study assessed brain CT perfusion and angiography for confirming death by neurologic criteria, highlighting high sensitivity but suboptimal specificity, emphasizing cautious use alongside clinical examination.
This article reviews current evidence and clinical practices for physiotherapy in ICU settings, emphasizing benefits, safety, staffing challenges, and future directions in critical care rehabilitation.
The SIPS surgical handover system significantly improves handover quality, patient vital signs, and staff safety perceptions without prolonging meeting times, enhancing safety in emergency general surgery.
This study developed and validated machine learning models with high accuracy to predict early pediatric sepsis and septic shock within 48 hours using multisite electronic health record data in emergency departments.
This qualitative UK study explores older patients’ perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical appr
The PRETREAT trial found that proactive blood pressure management tailored by risk of intraoperative hypotension does not reduce postoperative functional disability compared to standard care in noncardiac surgery.
The IMPROVE-multi randomized clinical trial found that tailoring perioperative blood pressure targets to individual preoperative nighttime MAP levels did not reduce postoperative organ injury or mortality compared to routine management in h
The ARON trial demonstrated that a clinical decision tool combining decision tree, point-of-care CRP testing, and safety-netting advice safely reduces antibiotic prescribing in acutely ill children without delaying recovery or increasing he
A WHO meta-analysis reveals that combining lower blood loss thresholds with abnormal vital signs improves prediction of severe postpartum hemorrhage outcomes, supporting earlier diagnosis and intervention.
A randomized clinical trial demonstrates that a novel avalanche safety device delaying hypoxia and hypercapnia can extend survival time beyond the critical 35-minute asphyxiation window during avalanche burial.
This trial found that adjunctive dexmedetomidine did not reduce opioid use, pain scores, or pulmonary complications in nonintubated ICU patients with traumatic rib fractures, challenging its routine analgesic use in this setting.
Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and CNS dysfunction, necessitating rapid recognition and intervention to prevent multi-organ failure and death. This article reviews its pathophysiol
This analysis reveals that standard initiation of kidney replacement therapy (KRT) in critically ill patients with severe acute kidney injury (AKI) offers greater quality-adjusted life years (QALYs) at an acceptable increased cost, suggesti
The Best Case/Worst Case-ICU communication tool supports trauma ICU teams in effectively discussing prognoses with families, improving decision-making and reducing distress, though implementation faces practical barriers.
