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De-escalating Axillary Surgery in Early Breast Cancer: Implementing SOUND and INSEMA Trials in Clinical Practice
General SurgerySOUND trialPhẫu thuật Hố nách

De-escalating Axillary Surgery in Early Breast Cancer: Implementing SOUND and INSEMA Trials in Clinical Practice

By MedXY|Oct 17, 2026

Omission of sentinel lymph node biopsy (SLNB) in select postmenopausal patients with early HR+/HER2- breast cancer and negative axillary ultrasound is feasible and safe, reducing surgical morbidity without compromising short-term outcomes.

Reevaluating Sentinel Lymph Node Biopsy in Older Women with cT2N0 HR+/HER2- Breast Cancer: Limited Impact on Treatment Decisions
General Surgeryadjuvant therapy
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breast cancer

Reevaluating Sentinel Lymph Node Biopsy in Older Women with cT2N0 HR+/HER2- Breast Cancer: Limited Impact on Treatment Decisions

By MedXY|Oct 4, 2026

In women aged 65 and older with cT2N0 hormone receptor-positive, HER2-negative breast cancer, sentinel lymph node biopsy rarely alters adjuvant therapy plans, supporting a more individualized approach to axillary staging in this population.

Axillary Nodal Upstaging in cT1N0 Invasive Lobular Carcinoma: Assessing Sentinel Lymph Node Biopsy Omission Based on SOUND Trial Evidence
Clinical Updatesaxillary staginginvasive lobular carcinoma

Axillary Nodal Upstaging in cT1N0 Invasive Lobular Carcinoma: Assessing Sentinel Lymph Node Biopsy Omission Based on SOUND Trial Evidence

By MedXY|Oct 1, 2026

This review evaluates whether sentinel lymph node biopsy omission, validated in SOUND and INSEMA trials, applies to cT1N0 invasive lobular carcinoma, highlighting nodal positivity rates, risk factors such as lymphovascular invasion, and cli

Contemporary Surgical Management of Vulvar Cancer: Balancing Improved Survival with Increased Reoperation Rates — Insights from a Finnish Nationwide Study
Clinical UpdatesSentinel Lymph Node Biopsyreoperation

Contemporary Surgical Management of Vulvar Cancer: Balancing Improved Survival with Increased Reoperation Rates — Insights from a Finnish Nationwide Study

By MedXY|Sep 27, 2026

This review synthesizes evidence that modern personalized surgical strategies for vulvar squamous cell carcinoma enhance survival outcomes despite higher reoperation rates, emphasizing evolving surgical techniques, sentinel lymph node biops

Advancing Sentinel Lymph Node Biopsy in Vulvar Cancer: Real-Time Near-Infrared Fluorescence Imaging Enhances Detection and Safety
newsIndocyanine GreenSentinel Lymph Node Biopsy

Advancing Sentinel Lymph Node Biopsy in Vulvar Cancer: Real-Time Near-Infrared Fluorescence Imaging Enhances Detection and Safety

By MedXY|Sep 25, 2026

A recent study demonstrates the feasibility and safety of hybrid indocyanine green and technetium-99m nanoparticle fluorescence imaging for sentinel lymph node biopsy in early-stage vulvar cancer, improving detection rates and oncologic out

Clinical Impact of Sentinel Lymph Node Biopsy in Atypical Endometrial Hyperplasia: Insights from a Multicenter Cohort Study
newsSentinel Lymph Node Biopsyatypical endometrial hyperplasia

Clinical Impact of Sentinel Lymph Node Biopsy in Atypical Endometrial Hyperplasia: Insights from a Multicenter Cohort Study

By MedXY|Aug 26, 2026

Sentinel lymph node biopsy in atypical endometrial hyperplasia patients identifies occult cancers and refines adjuvant treatment strategies, supporting its safe and feasible use for better risk stratification.

Quality of Life and Morbidity Outcomes After Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-Stage Cervical Cancer: Insights from the SENTIX Study
newsSentinel Lymph Node Biopsylymphoedema

Quality of Life and Morbidity Outcomes After Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-Stage Cervical Cancer: Insights from the SENTIX Study

By MedXY|Aug 17, 2026

The SENTIX study demonstrates that sentinel lymph node biopsy preserves quality of life, reduces lymphoedema incidence, and lowers early postoperative complications compared to pelvic lymphadenectomy in early-stage cervical cancer patients.

Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma: Why High False-Negative Rates Demand Clinical Vigilance
newshead and neck oncologyMerkel Cell Carcinoma

Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma: Why High False-Negative Rates Demand Clinical Vigilance

By MedXY|Mar 18, 2026

A comprehensive cohort study reveals that sentinel lymph node biopsy (SLNB) in head and neck Merkel cell carcinoma has a sensitivity of only 52.6% and a high failure rate. The findings suggest that clinicians must reconsider management stra

The Precision Gap: Evaluating Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma
newshead and neck cancerMerkel Cell Carcinoma

The Precision Gap: Evaluating Sentinel Lymph Node Biopsy in Head and Neck Merkel Cell Carcinoma

By MedXY|Jan 30, 2026

This article examines the clinical accuracy of Sentinel Lymph Node Biopsy for head and neck Merkel cell carcinoma, highlighting a significant false-negative rate and identifying risk factors that necessitate more personalized treatment stra

Refining Sentinel Lymph Node Biopsy Decisions in Melanoma: Insights from the MERLIN_001 Gene Expression Profiling Study
Dermatologymelanomarisk stratification

Refining Sentinel Lymph Node Biopsy Decisions in Melanoma: Insights from the MERLIN_001 Gene Expression Profiling Study

By MedXY|Oct 24, 2025

The MERLIN_001 study validates a combined clinicopathological and gene expression profile test that accurately predicts sentinel lymph node metastasis risk in patients with cutaneous melanoma, potentially guiding safer, more personalized su

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