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Reevaluating Sentinel Lymph Node Biopsy in Older Women with cT2N0 HR+/HER2- Breast Cancer: Limited Impact on Treatment Decisions

MedXY Editorial Team•Oct 4, 2026•General Surgery
adjuvant therapybreast cancerHormone Receptor-Positiveolder womenSentinel Lymph Node Biopsy

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Sentinel lymph node biopsy (SLNB) has limited influence on adjuvant treatment decisions in women aged 65 years or older with clinical T2N0 hormone receptor-positive/HER2-negative breast cancer. Chemotherapy choices were primarily driven by genomic assays rather than nodal status, and most node-positive patients did not receive regional nodal irradiation. These results support a selective, individualized approach to axillary staging in this patient group.

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