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Cases of High-Titer Inhibitor Formation After AAV Gene Therapy for Hemophilia A
Hematology-Oncologycase reportgene therapy

Cases of High-Titer Inhibitor Formation After AAV Gene Therapy for Hemophilia A

By MedXY|Oct 20, 2026

Two hemophilia A patients developed persistent high-titer FVIII inhibitors following AAV-mediated gene therapy with a bioengineered FVIII transgene despite prior extensive FVIII exposure.

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