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Solid organ transplant recipients have increased risk of HPV-driven anal dysplasia and cancer due to unique immune alterations from immunosuppression. This article explores the transplant-specific immune dysfunction underlying persistent HP
Despite identical immunogenetic makeup, half of kidney transplant recipients from identical twins remain on calcineurin inhibitors, with no demonstrable benefit in rejection reduction or graft survival over 25 years, calling for critical re
A multi-centre phase 2 study demonstrates that belatacept combined with sirolimus achieves superior islet transplant outcomes with better renal preservation compared to conventional tacrolimus-based therapy in type 1 diabetes patients.
This study unravels how tumour-derived NGAL induces NETs that reprogram fibroblast subtypes via ITGA5, promoting immunosuppression and tumour progression in pancreatic ductal adenocarcinoma, suggesting combinatorial therapies to enhance imm
This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.
A 20-year retrospective study of 6,452 solid organ transplant patients reveals hepatitis E infection rates of 3.5%, with chronicity rates exceeding 65%. The findings highlight the critical importance of HEV screening and the effectiveness o
This article explores a major international study of 156 acute eosinophilic myocarditis patients, revealing high mortality rates, the diagnostic necessity of endomyocardial biopsy, and the critical survival benefit of early immunosuppressiv
A large-scale cohort study reveals that solid organ transplant recipients with pre-existing cancer histories face significantly elevated risks for subsequent malignancies, particularly recurring or de novo cancers of the same type, necessit
A landmark multicenter study of 156 patients reveals that acute eosinophilic myocarditis frequently presents without peripheral eosinophilia, carries a high risk of death or heart transplant, and requires early immunosuppressive therapy to
A phase 4 RCT in Brazil confirms that the recombinant zoster vaccine does not increase the risk of disease flares in patients with autoimmune rheumatic diseases compared to placebo, maintaining a favorable safety profile even under immunosu
Large-scale cohort and prospective data reveal that monocyte HLA-DR expression is a dynamic predictor of ICU-acquired infections and mortality, offering a roadmap for personalized immunostimulant therapy in septic shock and transplant patie
Single‑cell and spatial profiling identify a PDE5A+ CAF subset that remodels stroma, activates PI3K/AKT/mTOR–CXCL12 signaling, and recruits exhausted LAG3+ CD8 T cells, promoting immune exclusion in gastric cancer. Vardenafil plus LAG3 bloc
This randomized trial evaluates the safety and efficacy of everolimus combined with low-dose tacrolimus versus standard immunosuppression in children 6 months post-heart transplant, highlighting comparable rejection rates, improved kidney f
A retrospective cohort study demonstrates that implementation of KP-SUNTRAC increases targeted skin cancer screening and detection among high-risk solid organ transplant recipients without increasing health care utilization.
Since the landmark combined liver–kidney transplant in 1984, advances in surgical techniques, immunosuppression, and donor allocation have revolutionized care for patients with dual organ failure. Emerging innovations, including gene-edited
This article reviews the immunosuppressive mechanisms of tumour-infiltrating B cells in intrahepatic cholangiocarcinoma (iCCA), their impact on prognosis, and potential to enhance chemoimmunotherapy efficacy by restoring B-cell function and