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Combined Liver–Kidney Transplantation: Four Decades of Transformative Impact and Future Horizons

Since the landmark combined liver–kidney transplant in 1984, advances in surgical techniques, immunosuppression, and donor allocation have revolutionized care for patients with dual organ failure. Emerging innovations, including gene-edited

Sep 25, 2025
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Immunosuppressive Roles of Tumour-Infiltrating B Cells in Intrahepatic Cholangiocarcinoma and Implications for Chemoimmunotherapy Outcomes

This article reviews the immunosuppressive mechanisms of tumour-infiltrating B cells in intrahepatic cholangiocarcinoma (iCCA), their impact on prognosis, and potential to enhance chemoimmunotherapy efficacy by restoring B-cell function and

Sep 4, 2025
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