Malignancy Risk Patterns in Solid Organ Transplant Recipients with a History of Pretransplant Cancer
Highlights
- Solid organ transplant (SOT) recipients with a pretransplant cancer history have a significantly increased risk of developing the same type of cancer posttransplant.
- The highest risk association was observed for melanoma, with an incidence rate ratio (IRR) of 10.4.
- Specific cross-cancer associations exist, such as pretransplant kidney cancer increasing the risk of posttransplant thyroid cancer.
- Risk levels for certain cancers (liver, kidney, lung) in SOT recipients were lower than standardized incidence ratios (SIRs) seen in cancer survivors in the general population, suggesting complex interactions between organ disease and immunosuppression.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.