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Immunosuppression and Long-term Survival After Single Living-donor Lobar Lung Transplantation from the Same Donor as Prior Hematopoietic Stem Cell Transplantation: An All-Japan Case Series
Hematology-Oncologyimmunosuppressioncase report

Immunosuppression and Long-term Survival After Single Living-donor Lobar Lung Transplantation from the Same Donor as Prior Hematopoietic Stem Cell Transplantation: An All-Japan Case Series

By MedXY|Oct 18, 2026

This case series examines immunosuppressive management and long-term outcomes in nine Japanese patients undergoing single living-donor lobar lung transplantation from the same donor as prior HSCT, revealing viable reduced immunosuppression

Targeting PPM1D Overexpression in Myeloproliferative Neoplasms: Molecular Insights and Therapeutic Advances
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Hematology-Oncology
targeted therapy
Myeloproliferative Neoplasms

Targeting PPM1D Overexpression in Myeloproliferative Neoplasms: Molecular Insights and Therapeutic Advances

By MedXY|Oct 18, 2026

PPM1D mutations and overexpression are involved in MPN pathogenesis, with dual PPM1D and HDM2 inhibition emerging as a promising therapeutic strategy, particularly for myelofibrosis patients.

Impact of Conditioning Regimens on Pregnancy Outcomes in Female Survivors of Childhood and Adolescent Acute Leukemia: HSCT versus Conventional Chemotherapy
Hematology-Oncology妊娠成績total body irradiation

Impact of Conditioning Regimens on Pregnancy Outcomes in Female Survivors of Childhood and Adolescent Acute Leukemia: HSCT versus Conventional Chemotherapy

By MedXY|Sep 12, 2026

This multicenter study reveals that total-body irradiation (TBI) conditioning before hematopoietic stem cell transplantation severely compromises pregnancy outcomes compared to alkylating agents or conventional chemotherapy in female surviv

Fecal Microbiota Transplantation: A Promising Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease
Gastroenterologygut microbiomesteroid-refractory

Fecal Microbiota Transplantation: A Promising Therapy for Steroid-Refractory Acute Graft-Versus-Host Disease

By MedXY|Aug 27, 2026

This retrospective multicenter study evaluates fecal microbiota transplantation (FMT) for steroid-refractory acute graft-versus-host disease (aGvHD), demonstrating a 60.5% response at day 28 and highlighting FMT’s potential as a safe

Reassessing Total Body Irradiation in Young Children with ALL: Long-Term Safety and Outcomes
Hematology-Oncologypediatric ALLtotal body irradiation

Reassessing Total Body Irradiation in Young Children with ALL: Long-Term Safety and Outcomes

By MedXY|Aug 24, 2026

A French longitudinal study finds no increased long-term complications or compromised quality of life in children under 4 years undergoing TBI-based HSCT for acute lymphoblastic leukemia, challenging prior age restrictions.

Ovarian Tissue Cryopreservation After Hematopoietic Stem Cell Transplantation: A Viable Fertility Preservation Strategy in Selected Females
Hematology-OncologyDự trữ buồng trứngOvarian tissue cryopreservation

Ovarian Tissue Cryopreservation After Hematopoietic Stem Cell Transplantation: A Viable Fertility Preservation Strategy in Selected Females

By MedXY|Aug 20, 2026

This study evaluates ovarian tissue cryopreservation (OTC) feasibility in girls and young women post-hematopoietic stem cell transplantation (HSCT), demonstrating OTC as a potential fertility salvage option despite reduced ovarian reserve a

Metabolic Regulation of Human Hematopoietic Stem and Progenitor Cell Regeneration by l-Carnitine: Mechanistic Insights and Therapeutic Implications
Clinical UpdatesL-Carnitineregenerative medicine

Metabolic Regulation of Human Hematopoietic Stem and Progenitor Cell Regeneration by l-Carnitine: Mechanistic Insights and Therapeutic Implications

By MedXY|Aug 12, 2026

This review synthesizes evidence revealing l-carnitine’s pivotal role in human hematopoietic stem and progenitor cell regeneration via fatty acid oxidation, highlighting metabolic profiling advances and translational potential for reg

Reduced-Intensity Thiotepa Plus Post-Transplant Cyclophosphamide Delivers Near-Universal Engraftment and Minimal GVHD in Matched Sibling Transplantation for Adolescents and Adults With Sickle Cell Disease
Hematology-Oncologyhematopoietic stem cell transplantationposttransplant cyclophosphamide

Reduced-Intensity Thiotepa Plus Post-Transplant Cyclophosphamide Delivers Near-Universal Engraftment and Minimal GVHD in Matched Sibling Transplantation for Adolescents and Adults With Sickle Cell Disease

By MedXY|May 4, 2026

A prospective multicenter study reports excellent survival, no graft failure, and very low GVHD with a thiotepa-based reduced-intensity matched sibling transplant platform for severe sickle cell disease.

Breaking the Cystine Barrier: Long-term Safety and Efficacy of CTNS-RD-04 Gene Therapy in Cystinosis
Hematology-Oncologygene therapyhematopoietic stem cell transplantation

Breaking the Cystine Barrier: Long-term Safety and Efficacy of CTNS-RD-04 Gene Therapy in Cystinosis

By MedXY|Feb 22, 2026

A phase 1-2 trial shows that autologous hematopoietic stem-cell gene therapy (CTNS-RD-04) safely reduces lysosomal cystine levels in patients with cystinosis, potentially offering a definitive alternative to lifelong cysteamine therapy.

Beyond the CNS and Skeleton: HSPC-Gene Therapy (OTL-203) Demonstrates Superior Multi-System Efficacy in Hurler Syndrome
Hematology-Oncologygene therapyhematopoietic stem cell transplantation

Beyond the CNS and Skeleton: HSPC-Gene Therapy (OTL-203) Demonstrates Superior Multi-System Efficacy in Hurler Syndrome

By MedXY|Jan 20, 2026

A clinical study comparing OTL-203 gene therapy to allogeneic HSCT for Hurler syndrome reveals significant improvements in corneal clarity, hearing preservation, and cardiac stability, marking a potential shift in the standard of care for m

Non‑conditioned Autologous Gene Therapy Reverses Bone Marrow Failure in Fanconi Anaemia‑A: FANCOLEN‑1 Phase 1/2 and Long‑Term Outcomes
Hematology-OncologyFanconi anaemiagene therapy

Non‑conditioned Autologous Gene Therapy Reverses Bone Marrow Failure in Fanconi Anaemia‑A: FANCOLEN‑1 Phase 1/2 and Long‑Term Outcomes

By MedXY|Nov 11, 2025

The FANCOLEN‑1 trial shows that infusion of autologous FANCA‑corrected CD34+ cells without cytotoxic conditioning produced sustained engraftment and clinical improvement in a majority of treated patients with Fanconi anaemia‑A, with an acce

Multisite Randomized Trial of Inpatient Palliative Care in Hematopoietic Stem Cell Transplantation: Enhancing Patient and Caregiver Outcomes
Clinical Updateshematopoietic stem cell transplantationpalliative care

Multisite Randomized Trial of Inpatient Palliative Care in Hematopoietic Stem Cell Transplantation: Enhancing Patient and Caregiver Outcomes

By MedXY|Sep 9, 2025

Inpatient palliative care during hematopoietic stem cell transplantation improves patients’ quality of life, reduces depression and PTSD symptoms, and offers sustained psychological benefits up to six months post-transplant.

Improving Outcomes in Mismatched Unrelated Donor Stem Cell Transplants With Post-Transplant Cyclophosphamide
Clinical Updatesgraft-versus-host diseasehematopoietic stem cell transplantation

Improving Outcomes in Mismatched Unrelated Donor Stem Cell Transplants With Post-Transplant Cyclophosphamide

By MedXY|Sep 9, 2025

Post-transplant cyclophosphamide (PTCy) for graft-versus-host disease prophylaxis significantly improves 1-year survival and lowers severe GVHD rates in mismatched unrelated donor peripheral blood stem cell transplants, expanding access for

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