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Transcatheter Edge-to-Edge Repair Superior to Medical Therapy in Atrial Functional Mitral Regurgitation: Evidence from Real-World Registries

Transcatheter Edge-to-Edge Repair Superior to Medical Therapy in Atrial Functional Mitral Regurgitation: Evidence from Real-World Registries

A propensity score-based study demonstrates that transcatheter edge-to-edge repair (TEER) significantly reduces mortality and heart failure hospitalizations in patients with atrial functional mitral regurgitation compared to medical therapy

Section: CardiologyMar 18, 2026

Coronary Artery Calcium Scoring Remains the Definitive Risk Stratifier for Patients With Elevated Lipoprotein(a)

Coronary Artery Calcium Scoring Remains the Definitive Risk Stratifier for Patients With Elevated Lipoprotein(a)

A large multicohort study involving 11,319 participants confirms that Coronary Artery Calcium (CAC) scoring effectively stratifies cardiovascular risk even in individuals with high Lipoprotein(a), providing clinical clarity for personalized

Section: CardiologyMar 17, 2026

Moderate Mixed Aortic Valve Disease: Why Moderate Severity Carries Severe Risk

Moderate Mixed Aortic Valve Disease: Why Moderate Severity Carries Severe Risk

A large-scale multicenter study demonstrates that moderate mixed aortic valve disease (MAVD) carries a mortality risk comparable to severe aortic stenosis when symptoms or left ventricular dysfunction are present, challenging current guidel

Section: CardiologyMar 15, 2026

TRIM28: A Novel E3 Ubiquitin Ligase Guarding the Heart Against Ischemia/Reperfusion-Induced Ferroptosis

TRIM28: A Novel E3 Ubiquitin Ligase Guarding the Heart Against Ischemia/Reperfusion-Induced Ferroptosis

New research identifies TRIM28 as a critical E3 ubiquitin ligase that degrades IRP2, thereby suppressing iron uptake and preventing myocardial ferroptosis during ischemia/reperfusion injury. This pathway, activated by p55γ and the drug perh

Section: CardiologyMar 12, 2026

Novel Handheld Device More Than Doubles Success Rates of Valsalva Maneuver in Supraventricular Tachycardia: A Randomized Clinical Trial

Novel Handheld Device More Than Doubles Success Rates of Valsalva Maneuver in Supraventricular Tachycardia: A Randomized Clinical Trial

A randomized clinical trial published in JAMA Cardiology demonstrates that a handheld Valsalva assist device significantly improves sinus rhythm restoration in SVT patients, achieving a 63.2% success rate compared to just 29.2% with standar

Section: CardiologyMar 11, 2026

Severe Obesity Triples Heart Failure Risk: New Insights from the Cross-Cohort Collaboration

Severe Obesity Triples Heart Failure Risk: New Insights from the Cross-Cohort Collaboration

A massive study of nearly 290,000 participants reveals that severe obesity (BMI ≥40) triples the risk of heart failure and nearly triples the risk of atrial fibrillation, with significant sex-based differences in stroke and mortality risk.

Section: CardiologyMar 11, 2026

Beyond the Culprit: Unmasking the Prevalence and Fate of Silent Plaque Ruptures in Non-Infarct-Related Arteries

Beyond the Culprit: Unmasking the Prevalence and Fate of Silent Plaque Ruptures in Non-Infarct-Related Arteries

A landmark multimodality imaging study reveals that silent plaque ruptures occur in 12% of non-obstructive lesions in AMI patients. Over 50% of these ruptures heal within a year, highlighting the dynamic nature of coronary atherosclerosis a

Section: CardiologyMar 10, 2026

Misaligned Urgency: Why Status Exceptions May Be Paradoxically Lowering Priority for the Sickest Children in Heart Transplantation

Misaligned Urgency: Why Status Exceptions May Be Paradoxically Lowering Priority for the Sickest Children in Heart Transplantation

A large-scale analysis of 6,026 pediatric heart transplant candidates reveals that status exceptions often prioritize patients with lower mortality risk than those meeting standard criteria, highlighting a significant misalignment in the U.

Section: CardiologyMar 10, 2026

Varenicline and Ventricular Ectopy After Myocardial Infarction: A Randomized Phase 2 Study

Varenicline and Ventricular Ectopy After Myocardial Infarction: A Randomized Phase 2 Study

This phase 2 trial demonstrates that varenicline, a partial nAChR agonist, significantly reduces premature ventricular complexes and nonsustained ventricular tachycardia in post-myocardial infarction patients, offering a novel therapeutic t

Section: CardiologyMar 10, 2026

Beyond the Gradient: Invasive Exercise Hemodynamics Confirm Discordant Low-Gradient Aortic Stenosis as a High-Risk Phenotype

Beyond the Gradient: Invasive Exercise Hemodynamics Confirm Discordant Low-Gradient Aortic Stenosis as a High-Risk Phenotype

A pivotal study using invasive exercise hemodynamics reveals that discordant low-gradient aortic stenosis behaves similarly to high-gradient severe disease, often masking underlying heart failure with preserved ejection fraction (HFpEF) phy

Section: CardiologyMar 10, 2026

Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial

Low-Dose Rivaroxaban to Prevent Left Ventricular Thrombosis After Anterior Myocardial Infarction: The APERITIF Randomized Clinical Trial

The APERITIF trial explored adding low-dose rivaroxaban to standard dual antiplatelet therapy to prevent heart clots after an anterior heart attack. While the addition did not significantly reduce thrombus formation, it did increase minor b

Section: CardiologyMar 10, 2026

Superior Long-Term Hemodynamics with Self-Expanding Valves in Small Failed Bioprostheses: 3-Year Insights from the LYTEN Trial

Superior Long-Term Hemodynamics with Self-Expanding Valves in Small Failed Bioprostheses: 3-Year Insights from the LYTEN Trial

The 3-year analysis of the LYTEN trial reveals that self-expanding valves (SEV) significantly outperform balloon-expandable valves (BEV) in hemodynamic metrics for valve-in-valve TAVR in patients with small surgical bioprostheses, although

Section: CardiologyMar 3, 2026

Rethinking Mitral Regurgitation in Hypertrophic Cardiomyopathy: Prognostic Impact Varies Significantly by Subtype

Rethinking Mitral Regurgitation in Hypertrophic Cardiomyopathy: Prognostic Impact Varies Significantly by Subtype

The REVEAL-HCM study demonstrates that while mitral regurgitation is a frequent comorbidity in hypertrophic cardiomyopathy, its prognostic impact is highly subtype-specific, significantly affecting outcomes in non-obstructive subtypes but s

Section: CardiologyMar 3, 2026

Beyond Peripheral Blood: Why Biopsy is the Gold Standard for Acute Eosinophilic Myocarditis

Beyond Peripheral Blood: Why Biopsy is the Gold Standard for Acute Eosinophilic Myocarditis

A landmark multicenter study of 156 patients reveals that acute eosinophilic myocarditis frequently presents without peripheral eosinophilia, carries a high risk of death or heart transplant, and requires early immunosuppressive therapy to

Section: CardiologyMar 3, 2026

Predicting Cardiovascular Outcomes in Fabry Disease: Identifying High-Risk Markers in the Modern Therapeutic Era

Predicting Cardiovascular Outcomes in Fabry Disease: Identifying High-Risk Markers in the Modern Therapeutic Era

A multicenter study of 680 Fabry disease patients reveals that age, renal function, QRS duration, and left ventricular mass are critical independent predictors of major adverse cardiovascular events, highlighting persistent unmet needs desp

Section: CardiologyMar 3, 2026

Long-Term Prognosis of Acute Myocardial Infarction Caused by Isolated Diffuse Coronary Artery Ectasia

Long-Term Prognosis of Acute Myocardial Infarction Caused by Isolated Diffuse Coronary Artery Ectasia

Patients with myocardial infarction due to isolated coronary artery ectasia face a significantly higher risk of recurrent MI and stent thrombosis compared to those without ectasia, highlighting the need for specialized long-term management.

Section: CardiologyMar 3, 2026

Angiographic Burden of Coronary Atherosclerosis: The Critical Mediator Between ASCVD Risk Factors and Cardiovascular Outcomes

Angiographic Burden of Coronary Atherosclerosis: The Critical Mediator Between ASCVD Risk Factors and Cardiovascular Outcomes

This Mendelian randomization study reveals that coronary plaque burden significantly mediates the link between traditional risk factors and adverse events like myocardial infarction and heart failure, reinforcing the necessity of early prim

Section: CardiologyMar 2, 2026

NOACs Superior to Warfarin for Systemic Embolic Events: Lessons from a 71,683-Patient Meta-Analysis

NOACs Superior to Warfarin for Systemic Embolic Events: Lessons from a 71,683-Patient Meta-Analysis

A large-scale individual patient data meta-analysis reveals that while systemic embolic events are less common than strokes in atrial fibrillation, they carry an equivalent mortality risk. NOACs significantly reduce this risk by 29% compare

Section: CardiologyMar 2, 2026

The Rising Tide of Cardiovascular Disease: AHA’s 2050 Forecast for Women’s Heart Health

The Rising Tide of Cardiovascular Disease: AHA’s 2050 Forecast for Women’s Heart Health

A major AHA scientific statement forecasts a significant increase in cardiovascular disease and risk factors among U.S. women by 2050. It highlights rising rates of obesity and hypertension while emphasizing the urgent need for targeted int

Section: CardiologyMar 2, 2026

Long-Term Clinical Outcomes After Patent Foramen Ovale (PFO) Closure: A 20-Year Follow-Up Study

Long-Term Clinical Outcomes After Patent Foramen Ovale (PFO) Closure: A 20-Year Follow-Up Study

This article examines the 20-year safety and efficacy of transcatheter PFO closure in patients with paradoxical embolism, highlighting low recurrence rates but significant long-term bleeding risks associated with antithrombotic therapy.

Section: CardiologyMar 2, 2026

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MedXY News - Cardiology