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Unveiling the Role of FOXF1 Variants in Pulmonary Arterial Hypertension Pathogenesis
CardiologyBMPR2FOXF1

Unveiling the Role of FOXF1 Variants in Pulmonary Arterial Hypertension Pathogenesis

By MedXY|Oct 16, 2026

Rare coding variants in the FOXF1 gene are linked to pulmonary arterial hypertension (PAH), implicating impaired endothelial FOXF1 expression and disrupted BMPR2 regulation in disease development.

The BMPR2 Nexus: How Breast Cancer Acts as a Second Hit for Pulmonary Hypertension
CardiologyBMPR2breast cancer

The BMPR2 Nexus: How Breast Cancer Acts as a Second Hit for Pulmonary Hypertension

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By MedXY|Mar 1, 2026

Emerging evidence identifies a bidirectional link between breast cancer and pulmonary arterial hypertension (PAH) driven by BMPR2 signaling and IL-1β-mediated inflammation. This study suggests breast cancer may serve as a critical second hi

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