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Exploring the Link Between Common Infections and Alzheimer’s Disease Neuropathology: Insights From a UK Prospective Cohort Study
Infectious Diseasesinfectionsneuropathology

Exploring the Link Between Common Infections and Alzheimer’s Disease Neuropathology: Insights From a UK Prospective Cohort Study

By MedXY|Oct 21, 2026

A large-scale UK cohort study found no strong associations between antibodies against multiple common infections and key Alzheimer’s disease neuropathologies, though possible interactions with APOE ε4 genotype and education warrant further

Why Women Show Higher Amyloid Burden: New Evidence on Sex, Race, and APOE ε4 Interactions in Alzheimer’s Pathology
NeurologyAlzheimer diseaseAPOE ε4

Why Women Show Higher Amyloid Burden: New Evidence on Sex, Race, and APOE ε4 Interactions in Alzheimer’s Pathology

By MedXY|Apr 13, 2026

A Brazilian autopsy study of 2,268 individuals reveals that female sex, APOE ε4 status, and African ancestry jointly influence amyloid pathology. Women showed 65% higher adjusted odds of neuritic plaques, and protective effects against amyl

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability
NeurologyAPOE ε4olfaction

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability

By MedXY|Nov 5, 2025

In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network os

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies
Neurologyagingamygdala

Amygdala Tau Pathology as a Key Contributor to Depressive Symptoms in Aging: Insights from Neuroimaging Studies

By MedXY|Oct 21, 2025

Amygdala tau accumulation in cognitively normal older adults correlates with worsening depressive symptoms, especially in APOE ε4 carriers, highlighting its role in neuropsychiatric changes during aging.

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients
NeurologyAPOE ε4Dementia

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients

By MedXY|Oct 21, 2025

The APOE ε4 allele significantly reduces survival in Parkinson’s disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo
Family Medicine & NutritionAPOE ε4cognitive decline

APOE ε4 Allele: A Key Driver of Cognitive Decline and Neurodegeneration in Older Adults from the Democratic Republic of the Congo

By MedXY|Oct 21, 2025

This study reveals that the APOE ε4 allele is linked to increased dementia prevalence, cognitive deficits, brain atrophy, and plasma biomarkers of neurodegeneration in older adults in the DRC, emphasizing its critical role in African popula

Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences
Internal Medicineamyloid betaAPOE ε4

Unraveling Blood-Based Biomarkers in Neurodegenerative Diseases: Insights from the Young Finns Study on Intergenerational and Metabolic Influences

By MedXY|Oct 20, 2025

This cohort study from the Young Finns Study elucidates factors influencing blood-based biomarkers for neurodegenerative diseases, highlighting age, APOE ε4 genotype, kidney function, metabolic parameters, and notable intergenerational asso

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials
Clinical UpdatesAlzheimer's diseaseAPOE ε4

Walking and Dietary Interventions Offer Cognitive Protection in APOE ε4 Carriers: New Evidence from Longitudinal and Multinational Trials

By MedXY|Jul 30, 2025

Regular walking and lifestyle interventions slow cognitive decline, especially in APOE ε4 carriers at heightened Alzheimer’s risk, with effects pronounced in women. Evidence underscores the value of simple activity and healthy diet for at-r

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