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A novel pediatric-specific atlas of US acute care regions was developed using Medicaid data, revealing distinct patterns in emergency and referral care and providing a foundation for targeted pediatric healthcare planning and quality improv
This study reveals multiple distinct molecular mechanisms, including epithelial and macrophage pathways, that contribute to residual asthma exacerbations in children treated with mepolizumab, highlighting the complexity of airway inflammati
Prompt opioid delivery in pediatric EDs for sickle cell pain significantly lowers hospitalization rates, with the greatest benefit seen when the first dose is given within 60 minutes and the second dose within 30 minutes.
A Spanish multicenter study reveals a sharp rise in pediatric invasive group A streptococcal infections and severity after 2022, highlighting emm1 strain predominance and risk factors for critical illness and mortality.
A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.
This study explores how early Epstein-Barr virus (EBV) infection and immune responses influence oral human papillomavirus (HPV) infections in children, revealing the interplay between EBV serology, paternal education, and oral HPV acquisiti
This study links EBV seropositivity to immune dysregulation and increased mortality in pediatric sepsis, highlighting potential pathways for targeted therapies.
This study analyzes the diagnosis and medication initiation of ADHD among children aged 3-5 across multiple US health systems, highlighting sociodemographic disparities and clinical practices.
This study evaluates clinical testing trends for COVID-19, influenza, and RSV among hospitalized children from 2016 to 2024, revealing shifts in testing frequency and identifying factors influencing test utilization.
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
This network meta-analysis of 49 RCTs demonstrates that digital health interventions, notably virtual reality, 2D videos, and 2D games, significantly reduce perioperative anxiety and pain and improve induction compliance in pediatric surgic
This article reviews recent studies on EBV transmission in pediatric kidney transplants, highlighting risk factors, monitoring strategies, and implications for reducing posttransplant lymphoproliferative disorder (PTLD).
A secondary analysis of a cluster-randomized trial found that portable HEPA purifiers modestly reduced viral diversity but did not significantly lower high respiratory viral exposure in elementary school classrooms, suggesting multi-faceted
This study examines how pandemic-related nonpharmaceutical interventions affected immunity development to Streptococcus pyogenes and common respiratory viruses in children aged 0-4 years, offering insights into rising invasive infections.
A European study reveals that COVID-19 nonpharmaceutical interventions led to reduced immunity against S pyogenes and RSV in children aged 3-4, potentially explaining the recent spike in severe infections.
Antiviral prescriptions for children at high risk of severe influenza in US pediatric emergency departments decreased by over 50% during the COVID-19 pandemic compared with prepandemic rates, despite unchanged treatment guidelines.
Two brothers with lamellar ichthyosis presented with enamel defects and dental caries; dental rehabilitation with preventive measures was completed alongside dermatologic care.
A large randomized trial in Mali demonstrated that mass azithromycin administration to infants aged 1–11 months did not reduce mortality compared to placebo, challenging previous findings in sub-Saharan Africa.
Regeneron’s DB-OTO gene therapy shows promising results in restoring natural hearing in children with profound hearing loss caused by OTOF gene mutations, with 75% achieving significant hearing improvement after a single treatment.
The phase 3 BRAVE-AA-PEDS trial demonstrates that baricitinib, a JAK inhibitor, significantly restores scalp, eyebrow, and eyelash hair in adolescents with severe alopecia areata, achieving up to 80% hair regrowth in recent-onset cases afte
