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This pilot study reveals that adjunctive pitolisant, a histamine-3 inverse agonist, is well tolerated and improves symptom scales in refractory restless legs syndrome, suggesting potential to address daytime consequences with minimal core s
This study explores how caloric restriction influences organ size and metabolic adaptation, using MRI data from the CALERIE 2 trial, revealing nuanced changes in energy expenditure linked to organ-specific tissue loss.
A 12-week trial in children with ASD demonstrates that a structured anti-inflammatory dietary protocol (NeuroGutPlus) exerts broader immunoregulatory effects than multi-strain probiotics, highlighting diet as a promising non-pharmacological
Genomic newborn screening shows promise for early detection of a wider range of diseases but raises significant technological, ethical, and equity challenges before becoming a universally accessible public health tool.
This cluster-randomized trial evaluated an automated tobacco cessation intervention for parents in pediatric primary care, finding no significant increase in 1-year quit rates but notable improvements in treatment engagement and smoking red
This review examines randomized clinical evidence that 100% oxygen during deferred cord clamping improves early oxygen saturation in extremely preterm infants without increasing morbidity, highlighting implications for neonatal resuscitatio
This article reviews early clinical results from a US single-center study on in utero embolization for fetal Vein of Galen malformation, highlighting potential survival benefits alongside risks of preterm delivery.
Elevated blood pressure at age 7 significantly increases the risk of premature cardiovascular mortality by mid-adulthood, underscoring the need for early-life blood pressure monitoring and intervention.
The MAGIC trial reveals midazolam’s superior efficacy over melatonin in reducing preoperative anxiety in children undergoing general anaesthesia, despite melatonin’s favorable safety profile. Challenges in recruitment and implications for f
Children with chronic physical illnesses face higher risks of mental health issues, partly due to early-life constraints on social and physical activities. Encouraging active play and social engagement may reduce these risks.
This multicenter study highlights the utility of 2D speckle tracking echocardiography for early detection and prognostication of left ventricular dysfunction in MIS-C, informing cardiovascular risk and management.
A large pragmatic trial demonstrates that daily emollient application starting before 9 weeks of age significantly reduces the risk of atopic dermatitis by 24 months in infants not selected for high risk, offering a feasible preventive appr
Pharmaceutical companies have significantly increased marketing payments to clinicians for ADHD medications, particularly targeting advanced practice clinicians. The impact of this trend on prescribing patterns and clinical benefits remains
A multicountry study across Asia demonstrates soluble TREM1’s superior accuracy over traditional clinical signs in predicting severe febrile illness in children, potentially transforming triage in resource-limited settings.
This phase I/II trial demonstrates that the live-attenuated intranasal RSV vaccine (RSVt) is immunogenic and well-tolerated in infants and toddlers, offering a potential new preventive option against RSV infection.
The MADDY study reveals that micronutrient supplementation in children with ADHD alters gut microbial diversity and composition, notably increasing beneficial butyrate-producing bacteria, potentially underpinning improved behavioral outcome
A randomized clinical trial demonstrates that varenicline, combined with behavioral counseling, markedly improves nicotine vaping cessation rates in youth aged 16-25 who vape daily and do not regularly smoke tobacco.
Longitudinal observational data reveal that as adolescents increase cigarette use, their immediate post-smoking mood stabilizes, with boys showing stabilization in background mood as well.
A tailored, app-supported exercise program delivered via mobile health significantly improves core ADHD symptoms and executive functions in children, demonstrating comparable effectiveness to traditional face-to-face exercise guidance.
Obesity increases, while higher physical activity decreases, risk of subsequent neoplasms among childhood cancer survivors, highlighting lifestyle intervention potential for cancer prevention.
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