Oncology
Latest news
826 articles · 20 / page
Precision in Prevention: The Role of Prediction-Augmented Shared Decision-Making in Enhancing Lung Cancer Screening Uptake
This review evaluates the impact of integrating risk-prediction models into shared decision-making for lung cancer screening, focusing on clinical implementation strategies that prioritize high-benefit populations.
Optimizing Patient-Centered Lung Cancer Screening: Insights from the MyLungHealth Randomized Clinical Trial
This review analyzes the MyLungHealth trial, demonstrating how EHR-integrated, patient-facing tools significantly improve lung cancer screening eligibility identification and CT ordering rates compared to clinician-facing support alone.
Active Surveillance Superior to Surgery for Quality of Life in Low-Risk Thyroid Cancer: Insights from a Global Meta-Analysis
A comprehensive meta-analysis demonstrates that patients with papillary thyroid microcarcinoma managed via active surveillance experience significantly better health-related quality of life and fewer treatment-related symptoms than those un
Survival in Cancer Patients with ARDS: The YELENNA Study Challenges ECMO Utility in Severe Cases
The YELENNA prospective study reveals a 73.2% 90-day mortality rate for cancer patients with ARDS. Crucially, venovenous ECMO provided no survival benefit in severe cases, prompting a re-evaluation of current clinical guidelines and goals-o
High-Sensitivity Troponin I: A Poor Predictor of Anthracycline-Induced Left Ventricular Dysfunction?
The Cardiac CARE trial reveals that high-sensitivity cardiac troponin I levels do not correlate with cumulative anthracycline dose and only weakly predict subsequent declines in left ventricular function, challenging existing risk-stratific
Cervical Stromal Involvement and Morphology Redefine LG-ESS Prognosis: Why Radiotherapy May Not Be the Answer
Recent studies on Low-Grade Endometrial Stromal Sarcoma (LG-ESS) identify cervical stromal involvement as a key prognostic marker and suggest that adjuvant radiotherapy offers no survival benefit, advocating for individualized, risk-adapted
Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis
A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c
Sacubitril-Valsartan Prevents Anthracycline-Induced Myocardial Dysfunction: Results from the SARAH Trial
The SARAH trial demonstrates that sacubitril-valsartan significantly reduces subclinical left ventricular dysfunction in patients with elevated troponin during anthracycline chemotherapy, potentially offering a new cardioprotective strategy
Rethinking Radical Surgery: Lobectomy Matches Total Thyroidectomy Outcomes in Intermediate-Risk PTC with Unilateral N1b Disease
A comprehensive meta-analysis suggests that for intermediate-risk papillary thyroid carcinoma with unilateral lateral lymph node metastasis, lobectomy provides oncological outcomes comparable to total thyroidectomy, challenging the necessit
Rethinking Radioactive Iodine Therapy for T1-T2 Papillary Thyroid Carcinoma with Lymph Node Metastasis: A Multicenter Analysis
A multicenter study in China demonstrates that radioactive iodine therapy may not significantly improve structural or biochemical response rates in T1-T2 stage papillary thyroid carcinoma with lymph node metastasis, highlighting the lymph n
Total Thyroidectomy Superior to Lobectomy for N1b Papillary Thyroid Carcinoma: Longitudinal Data Suggests Age-Dependent Survival Benefits
A large-scale SEER database study reveals that total thyroidectomy significantly improves disease-specific survival for patients with cN1b papillary thyroid cancer. However, this survival advantage is attenuated in younger populations, pote
De-escalating Management of N1b Papillary Thyroid Carcinoma: Are Total Thyroidectomy and RAI Mandatory for All?
A multicenter study challenges the mandatory use of total thyroidectomy and radioactive iodine in all patients with lateral neck metastasis (cN1b) papillary thyroid carcinoma, suggesting that lobectomy may offer comparable oncologic outcome
Thyroid Lobectomy and Neck Dissection Offer Comparable Survival to Total Thyroidectomy in Selected N1b Papillary Thyroid Carcinoma
A landmark propensity-matched study from Memorial Sloan Kettering Cancer Center demonstrates that thyroid lobectomy with neck dissection provides similar survival and recurrence outcomes to total thyroidectomy plus radioactive iodine for sp
Cyst Fluid Genomics Redefine Risk: Mixed-Type IPMNs Harbor Greater Malignant Potential Than Branch-Duct Variants
A large-scale cohort study demonstrates that mixed-type IPMNs have a three-fold higher prevalence of high-risk mutations compared to branch-duct variants, and that cyst fluid NGS provides superior diagnostic specificity over traditional cli
Occupation Matters: New Data Reveal Wide Disparities in US Cancer Mortality Among Working-Age Adults
A comprehensive population study of 450,453 deaths identifies specific occupations, including fishing, mining, and funeral services, with disproportionately high cancer mortality, suggesting a complex interplay of workplace exposures and st
Scaling Symptom Relief: EHR-Facilitated Collaborative Care Outperforms Surveillance Alone in Large-Scale Oncology Trial
The E2C2 trial demonstrates that integrating electronic health record (EHR)-facilitated collaborative care with symptom surveillance significantly reduces the burden of anxiety, depression, and fatigue in oncology patients compared to surve
Targeting MET Amplification: Vebreltinib Shows Robust Antitumor Activity in Advanced NSCLC
The Phase 2 KUNPENG trial demonstrates that vebreltinib, a selective MET inhibitor, achieves a 48.8% objective response rate in patients with MET-amplified advanced non-small-cell lung cancer, regardless of prior treatment history, offering
GLIAA Trial Results: Contrast-Enhanced MRI Remains the Gold Standard for Re-irradiation Planning in Recurrent Glioblastoma
The multicenter GLIAA trial demonstrated that FET-PET-guided target volume delineation for re-irradiation does not provide a progression-free survival benefit over standard contrast-enhanced T1-weighted MRI in patients with recurrent gliobl
Beyond Nodal Status: A New Risk Score Predicts Recurrence in Lymph Node-Negative Pancreatic Neuroendocrine Tumors
A multi-center study in JAMA Surgery introduces a validated 13-point risk score to identify recurrence risk in LN-negative PanNET patients, revealing that tumor size, grade, and lymphovascular invasion are critical prognostic drivers even w
Breaking the Data Silos: Why Sharing Clinical Trial Biospecimens Is Non-Negotiable for Cancer Care
A critical review of 29 breast cancer registrational trials reveals a significant gap in biomarker research dissemination, prompting a call for mandatory data and biospecimen sharing to accelerate personalized oncology and honor patient con
Browse by specialty
Open language-specific specialty feeds and department pages.