Cardiologyblood pressureendothelial dysfunction
Shear Stress-Induced Endothelial HEG1 Signalling: A Novel Pathway Linking Blood Flow to Blood Pressure Regulation
By MedXY|Apr 17, 2026
Researchers identify HEG1 as a critical flow-sensitive endothelial protein that regulates blood pressure through CUL3-mediated degradation of PHACTR1, linking reduced shear stress in hypertension to impaired NO production and vascular dysfu