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This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway

GastroenterologyIL-15

Systemic Inflammation

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway

By MedXY|Aug 21, 2026

Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.

Family Medicine & Nutritionappetite regulationgut-brain axis

The Gut’s Sixth Sense: How Your Microbiome Quietly Controls Appetite

By MedXY|Oct 5, 2025

Recent research unveils a ‘neurobiotic sense’ in the gut that detects bacterial molecules and regulates feeding through the gut-brain axis, reshaping our understanding of appetite control.

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