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Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis
GastroenterologyCD8+ T cellsTherapeutic targets

Gut: Targeting Kupffer Cell Autophagy May Be A Novel Approach to Modulate CD8+ T Cell Activation in Primary Biliary Cholangitis

By MedXY|Aug 24, 2026

This article explores how autophagy in Kupffer cells influences CD8+ T cell activation and contributes to primary biliary cholangitis, highlighting potential therapeutic interventions targeting macrophage autophagy to alleviate liver inflam

Statin Use and Reduced Hepatic Decompensation Risk in Primary Biliary Cholangitis: Insights from a Target Trial Emulation Study
Clinical Updates
hepatic decompensation
liver outcomes

Statin Use and Reduced Hepatic Decompensation Risk in Primary Biliary Cholangitis: Insights from a Target Trial Emulation Study

By MedXY|Aug 11, 2026

This review synthesizes evidence on statin therapy reducing hepatic decompensation and major adverse liver outcomes in primary biliary cholangitis, highlighting a recent robust target trial emulation study across diverse populations.

PBC-AIH Variant: New International Consensus Clarifies Diagnosis and Treatment
Gastroenterologyautoimmune hepatitisDelphi consensus

PBC-AIH Variant: New International Consensus Clarifies Diagnosis and Treatment

By MedXY|May 18, 2026

An international Delphi panel has standardized how to define, diagnose, and treat the PBC-AIH variant, emphasizing liver biopsy, periodic reassessment, and tailored immunosuppression for worse-risk patients.

Tackling Fatigue in Primary Biliary Cholangitis: Key Recommendations from the European Reference Network Position Paper
GastroenterologyfatigueSclerose cholangite primaria

Tackling Fatigue in Primary Biliary Cholangitis: Key Recommendations from the European Reference Network Position Paper

By MedXY|Nov 9, 2025

A clear, practical summary of the 2025 ERN position paper on fatigue in primary biliary cholangitis (PBC) — epidemiology, assessment, the ASK‑MEASURE‑TREAT algorithm, and research priorities.

Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis: Insights from the Phase 3 GLISTEN Trial and Related Studies
Clinical UpdatesSclerose cholangite primaria

Linerixibat for Cholestatic Pruritus in Primary Biliary Cholangitis: Insights from the Phase 3 GLISTEN Trial and Related Studies

By MedXY|Nov 8, 2025

This review synthesizes evidence from the phase 3 GLISTEN trial and preceding studies on linerixibat, an ileal bile acid transporter inhibitor, demonstrating its efficacy and safety in reducing cholestatic pruritus in primary biliary cholan

Seladelpar Significantly Reduces Itch and Sleep Disturbance in PBC: Pooled Phase 3 Evidence and Clinical Implications
GastroenterologypruritusSclerose cholangite primaria

Seladelpar Significantly Reduces Itch and Sleep Disturbance in PBC: Pooled Phase 3 Evidence and Clinical Implications

By MedXY|Nov 6, 2025

Pooled analysis of the ENHANCE and RESPONSE phase 3 trials shows seladelpar 10 mg reduces pruritus and sleep disturbance in patients with primary biliary cholangitis (PBC) and moderate-to-severe baseline itch versus placebo over 6 months, w

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