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Transseptal TMVR Using the SAPIEN M3 System: 1-Year Outcomes in Patients with Mitral Annular Calcification from the ENCIRCLE MAC Registry
CardiologyMitral Annular CalcificationSAPIEN M3

Transseptal TMVR Using the SAPIEN M3 System: 1-Year Outcomes in Patients with Mitral Annular Calcification from the ENCIRCLE MAC Registry

By MedXY|Oct 21, 2026

Transseptal transcatheter mitral valve replacement with the SAPIEN M3 system in patients with symptomatic mitral annular calcification shows sustained mitral regurgitation reduction, improved functional status, and meaningful quality-of-lif

Transseptal TMVR with the SAPIEN M3 Lowers 1‑Year Mortality/HF Rehospitalisation in Patients Unsuitable for Surgery or TEER
CardiologyMitral Regurgitation
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SAPIEN M3

Transseptal TMVR with the SAPIEN M3 Lowers 1‑Year Mortality/HF Rehospitalisation in Patients Unsuitable for Surgery or TEER

By MedXY|Nov 11, 2025

A multicountry, single‑arm pivotal trial of the SAPIEN M3 transseptal transcatheter mitral valve replacement (TMVR) in patients deemed unsuitable for surgery or TEER demonstrated a 1‑year composite rate of death or heart‑failure rehospitali

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