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Impact of Diagnosis-to-Treatment Interval on Outcomes in Follicular Lymphoma Undergoing Immunochemotherapy

Impact of Diagnosis-to-Treatment Interval on Outcomes in Follicular Lymphoma Undergoing Immunochemotherapy

Shorter diagnosis-to-treatment intervals independently predict worse outcomes in follicular lymphoma treated with immunochemotherapy, highlighting a novel prognostic factor beyond existing risk indices.

Section: Hematology-OncologyJul 1, 2026

Refining Prognostic Assessment in Perihilar Cholangiocarcinoma: The Clinical Utility of Dual Radial Margin Distance Cutoffs

Refining Prognostic Assessment in Perihilar Cholangiocarcinoma: The Clinical Utility of Dual Radial Margin Distance Cutoffs

This study identifies dual cutoff values of 0 and 1 mm for radial margin distance in perihilar cholangiocarcinoma, providing a simple and effective stratification tool for postoperative recurrence risk and survival prediction.

Section: General SurgeryJun 29, 2026

Revisiting Level VII Lymph Node Metastasis in Medullary Thyroid Cancer: A Crucial Prognostic Subgroup

Revisiting Level VII Lymph Node Metastasis in Medullary Thyroid Cancer: A Crucial Prognostic Subgroup

Level VII lymph node metastasis in medullary thyroid cancer signifies a highly aggressive phenotype with the poorest prognosis. Reclassifying level VII nodes as N1b improves prognostic accuracy and could refine staging and treatment strateg

Section: Diabetes & EndocrinologyJun 25, 2026

Cancer and Heart Failure in Scotland: Epidemiology, Interactions, and Prognostic Implications

Cancer and Heart Failure in Scotland: Epidemiology, Interactions, and Prognostic Implications

This review synthesizes evidence on the prevalence, incidence, and prognosis of cancer and heart failure comorbidity in Scotland, integrating recent cohort data and cardio-oncology research to inform clinical practice and future research di

Section: CardiologyJun 25, 2026

Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification

Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification

Recent heart-transplant studies show donor-derived cell-free DNA not only detects rejection but also predicts mortality and persistent graft dysfunction, especially when elevated at diagnosis. Evidence supports a shift from binary surveilla

Section: Clinical UpdatesJun 18, 2026

Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma

Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma

Machine learning identified two distinct bilateral hepatocellular carcinoma phenotypes with different tumor burdens, surgical approaches, and outcomes, suggesting preoperative risk stratification may improve patient selection and treatment

Section: GastroenterologyJun 4, 2026

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact

The AHA-proposed CRIS classification reclassified many cancer-associated strokes previously labeled cryptogenic and identified a subgroup with markedly worse survival, improving both etiologic clarity and prognostic stratification.

Section: Hematology-OncologyJun 3, 2026

Pathologic Myopia Globe Shape and Long-Term Prognosis

Pathologic Myopia Globe Shape and Long-Term Prognosis

Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.

Section: newsJun 2, 2026

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms

A multicenter retrospective study suggests that MDS with isolated del(5q) and TP53 multihit alterations has substantially better survival than other low-blast TP53-multihit MDS, challenging how this subgroup should be classified.

Section: Hematology-OncologyMay 9, 2026

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study

Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.

Section: Internal MedicineApr 27, 2026

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses

High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.

Section: Clinical UpdatesApr 24, 2026

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy

A study reveals that RV-PA coupling, measured by TAPSE/sPAP ratio, significantly predicts outcomes in HFrEF patients during GDMT up-titration, highlighting its potential as a treatment target.

Section: CardiologyApr 22, 2026

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy

A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p

Section: GastroenterologyApr 2, 2026

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis

A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression pat

Section: CardiologyMar 3, 2026

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia

A population-based study reveals that nearly one-quarter of TIA patients experience depression, which significantly increases the risk of mortality and disability, regardless of whether acute ischemic lesions are present on imaging.

Section: NeurologyJan 7, 2026

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial

A secondary analysis of the GALACTIC-HF trial demonstrates that hypermagnesemia, rather than hypomagnesemia, is significantly associated with increased cardiovascular death and worsening heart failure in patients with HFrEF, challenging cur

Section: CardiologyJan 1, 2026

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis

A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c

Section: newsDec 25, 2025

Frailty after Acute Myocardial Infarction: A Stronger Predictor of 1‑Year Death in Younger Patients Than in the Elderly

Frailty after Acute Myocardial Infarction: A Stronger Predictor of 1‑Year Death in Younger Patients Than in the Elderly

A large population study shows frailty is independently linked to worse 1‑year outcomes after AMI across ages, with the largest relative impact in patients under 55 — underscoring the need to assess frailty beyond geriatric populations.

Section: CardiologyDec 2, 2025

A Standardized RANO Resection Classification Links Supramaximal Surgery to Meaningful Survival Gains in IDH‑Mutant Grade 2 Glioma

A Standardized RANO Resection Classification Links Supramaximal Surgery to Meaningful Survival Gains in IDH‑Mutant Grade 2 Glioma

An international retrospective cohort (n=1,391) validates a four‑tier RANO classification of residual T2‑FLAIR volume: supramaximal resection confers the largest survival benefit, with graded, durable advantages for maximal versus submaxima

Section: NeurologyNov 30, 2025

Lean MASLD Is Not Benign: Higher Liver Events and Mortality in Normal-BMI Patients Across Three Large Cohorts

Lean MASLD Is Not Benign: Higher Liver Events and Mortality in Normal-BMI Patients Across Three Large Cohorts

A pooled analysis of three population cohorts shows lean MASLD carries higher risks of liver-related events and all-cause and liver-related mortality despite lower cardiovascular event risk compared with non-lean MASLD.

Section: GastroenterologyNov 7, 2025

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