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COMPASS-SCC: A Novel Prognostic and Staging System Enhancing Risk Stratification in Cutaneous Squamous Cell Carcinoma
DermatologyCOMPASS-SCCstaging system

COMPASS-SCC: A Novel Prognostic and Staging System Enhancing Risk Stratification in Cutaneous Squamous Cell Carcinoma

By MedXY|Oct 17, 2026

The COMPASS-SCC, developed from a large international cohort, offers improved prognostic accuracy for cutaneous squamous cell carcinoma compared to existing AJCC8 and BWH staging systems, aiding clinical decision-making for metastasis and m

Impact of Primary Melanoma Stage on Survival Outcomes in Advanced Disease: Insights from the Spanish Melanoma Registry GEM1801
Dermatologymelanoma
metastatic melanoma

Impact of Primary Melanoma Stage on Survival Outcomes in Advanced Disease: Insights from the Spanish Melanoma Registry GEM1801

By MedXY|Oct 13, 2026

Systemic relapse after stage I melanoma, though rare, portends higher tumor burden and poorer survival compared with relapse after stage II/III disease, as evidenced by data from 365 metastatic melanoma patients in the Spanish Melanoma Regi

Prognostic Significance of Telomere Length in Chronic Lymphocytic Leukemia Under Venetoclax-Based First-Line Therapy
Hematology-OncologyBệnh bạch cầu lympho mạn tính dòng B (Chronic Lymphocytic LeukemiaChiều dài telomere

Prognostic Significance of Telomere Length in Chronic Lymphocytic Leukemia Under Venetoclax-Based First-Line Therapy

By MedXY|Oct 11, 2026

Telomere length serves as an independent prognostic marker for progression-free survival in chronic lymphocytic leukemia patients treated with venetoclax-based regimens, highlighting its role in risk stratification during the modern targete

Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis: Enhancing Diagnostic and Prognostic Precision
newsChiều dài telomereGenetic biomarkers

Age-Adjusted Whole Genome Sequencing Telomere Length in Idiopathic Pulmonary Fibrosis: Enhancing Diagnostic and Prognostic Precision

By MedXY|Oct 11, 2026

Age-adjusted WGS-estimated telomere length improves identification of pathologically short telomeres and detection of telomere-related variants in IPF, associating with survival outcomes but offering limited survival prediction beyond clini

Polygenic Risk Score Enhances Diagnosis and Prognostic Stratification in Idiopathic Pulmonary Fibrosis
newsgeneticsIdiopathic Pulmonary Fibrosis

Polygenic Risk Score Enhances Diagnosis and Prognostic Stratification in Idiopathic Pulmonary Fibrosis

By MedXY|Oct 8, 2026

A polygenic risk score (PRS) significantly associates with IPF diagnosis and mortality, demonstrating potential for improving clinical risk stratification using real-world biobank data.

Harnessing Circulating Tumour DNA for Minimal Residual Disease Detection in Colorectal Cancer: Insights from the INTERCEPT Programme
Gastroenterologycirculating tumour DNAcolorectal cancer

Harnessing Circulating Tumour DNA for Minimal Residual Disease Detection in Colorectal Cancer: Insights from the INTERCEPT Programme

By MedXY|Oct 5, 2026

The INTERCEPT study demonstrates that longitudinal ctDNA testing effectively detects minimal residual disease post-curative treatment in colorectal cancer, enhancing recurrence prediction and refining risk stratification to guide future int

Cardiovascular-Kidney-Metabolic Multimorbidity in Heart Failure: Prevalence, Prognostic Impact, and Clinical Implications Across Ejection Fraction Phenotypes
Cardiologycardiovascular diseasechronic kidney disease

Cardiovascular-Kidney-Metabolic Multimorbidity in Heart Failure: Prevalence, Prognostic Impact, and Clinical Implications Across Ejection Fraction Phenotypes

By MedXY|Oct 5, 2026

Most heart failure patients harbor multiple cardiovascular-kidney-metabolic conditions, which independently escalate mortality and readmission risk, especially in HFrEF, underscoring the need for integrated management strategies tailored by

Soluble BCMA as a Key Biomarker Defining Tumor Phenotypes and Prognosis in Newly Diagnosed Multiple Myeloma
Hematology-Oncologyrisk stratificationprognosis

Soluble BCMA as a Key Biomarker Defining Tumor Phenotypes and Prognosis in Newly Diagnosed Multiple Myeloma

By MedXY|Sep 26, 2026

Soluble BCMA levels in newly diagnosed multiple myeloma patients reveal distinct tumor phenotypes and predict prognosis more strongly than tumor volume, enabling improved risk stratification and clinical decision-making.

Enhancing Prognosis in Stable Coronary Artery Disease: Insights from a Nationwide Cohort on FFR-CT
Cardiologycardiovascular riskStable Coronary Artery Disease

Enhancing Prognosis in Stable Coronary Artery Disease: Insights from a Nationwide Cohort on FFR-CT

By MedXY|Sep 25, 2026

This large nationwide study demonstrates that coronary CTA-derived FFR-CT strongly predicts future myocardial infarction, cardiovascular death, and revascularization, independent of traditional risk factors and stenosis severity, with a thr

Brain Natriuretic Peptide Levels as a Prognostic Biomarker After Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension
CardiologyprognosisBrain Natriuretic Peptide

Brain Natriuretic Peptide Levels as a Prognostic Biomarker After Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension

By MedXY|Sep 20, 2026

This study demonstrates that elevated brain natriuretic peptide (BNP) post-pulmonary endarterectomy strongly predicts mortality in chronic thromboembolic pulmonary hypertension (CTEPH), providing valuable prognostic information beyond persi

Molecular Stratification of Early-Stage Vulvar Squamous Cell Carcinoma: Prognostic Impact of HPV and TP53 Status
newsTP53HPV

Molecular Stratification of Early-Stage Vulvar Squamous Cell Carcinoma: Prognostic Impact of HPV and TP53 Status

By MedXY|Sep 19, 2026

This study highlights how HPV and TP53 molecular subtyping in stage I vulvar squamous cell carcinoma delineates survival outcomes and recurrence risks, supporting its role in personalized management strategies.

Cardiac Sarcoidosis: Nationwide Insights into Diagnosis, Management, and Outcomes from the MYSTICS Registry
Cardiologycardiac imagingimmunosuppressive therapy

Cardiac Sarcoidosis: Nationwide Insights into Diagnosis, Management, and Outcomes from the MYSTICS Registry

By MedXY|Sep 17, 2026

The MYSTICS Registry provides robust data on cardiac sarcoidosis, highlighting diagnostic challenges, treatment patterns, and prognostic differences among phenotypes, emphasizing tailored management strategies to improve patient outcomes.

Synergistic Impact of Age and Nerve Degeneration on Bell’s Palsy Recovery: Clinical Implications
NeurologyageBell's palsy

Synergistic Impact of Age and Nerve Degeneration on Bell’s Palsy Recovery: Clinical Implications

By MedXY|Sep 14, 2026

Older adults with severe nerve impairment in Bell’s palsy experience markedly poorer recovery, highlighting the critical role of early, aggressive intervention.

Enhancing Prognosis in Bell Palsy: Electrodiagnostic Testing Beyond House-Brackmann Grade
NeurologyBell palsyHouse-Brackmann grade

Enhancing Prognosis in Bell Palsy: Electrodiagnostic Testing Beyond House-Brackmann Grade

By MedXY|Sep 13, 2026

Electrodiagnostic tests, notably electroneuronography and electromyography, significantly improve prognosis prediction for Bell palsy recovery, including patients with moderate paralysis (H-B grade IV). These findings support broader use to

Decoding CPEB3-Regulated Alternative Polyadenylation: A New Genetic Lens on Hepatocellular Carcinoma Prognosis
GastroenterologyAlternative PolyadenylationCPEB3

Decoding CPEB3-Regulated Alternative Polyadenylation: A New Genetic Lens on Hepatocellular Carcinoma Prognosis

By MedXY|Sep 5, 2026

This article explores how genetic variants affect CPEB3-mediated alternative polyadenylation in hepatocellular carcinoma, revealing potential prognostic markers and therapeutic targets to improve patient survival.

From Pressure Metrics to Personalized Prognosis: Transforming Risk Assessment in Advanced Chronic Liver Disease
GastroenterologyNon-invasive testsrisk stratification

From Pressure Metrics to Personalized Prognosis: Transforming Risk Assessment in Advanced Chronic Liver Disease

By MedXY|Aug 31, 2026

A shift from static portal pressure thresholds to dynamic, non-invasive risk prediction models offers improved prognostic accuracy for decompensation in advanced chronic liver disease, enabling personalized patient management and better cli

MRI-Derived EOAD-Signature Atrophy as a Prognostic Biomarker in Early-Onset Mild Cognitive Impairment
NeurologyEarly-Onset Alzheimer Diseasemild cognitive impairment

MRI-Derived EOAD-Signature Atrophy as a Prognostic Biomarker in Early-Onset Mild Cognitive Impairment

By MedXY|Aug 27, 2026

Baseline cortical atrophy within an EOAD-specific brain signature predicts progression from mild cognitive impairment to dementia, providing a valuable MRI biomarker for individualized prognosis in early-onset Alzheimer disease.

TERT Promoter Variants and Age: Refining Prognostic Precision in Papillary Thyroid Carcinoma
newsTERT promoterage

TERT Promoter Variants and Age: Refining Prognostic Precision in Papillary Thyroid Carcinoma

By MedXY|Aug 23, 2026

This analysis reveals that TERT promoter mutations, increasingly prevalent with age, better predict poor outcomes in papillary thyroid carcinoma than age alone, offering enhanced risk stratification for clinical management.

Validating Liver Stiffness Measurement as a Prognostic Tool in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort
Gastroenterologytransplant-free survivalviêm ống mật xơ cứng nguyên phát

Validating Liver Stiffness Measurement as a Prognostic Tool in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort

By MedXY|Aug 13, 2026

This prospective study confirms that liver stiffness measurement (LSM) by Fibroscan® effectively predicts transplant-free survival in primary sclerosing cholangitis (PSC), highlighting both static and dynamic assessments as powerful risk st

Liver Stiffness Measurements as Prognostic Tools in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort
Gastroenterologyviêm ống mật xơ cứng nguyên phátliver stiffness measurement

Liver Stiffness Measurements as Prognostic Tools in Primary Sclerosing Cholangitis: Insights from the Prospective FICUS Cohort

By MedXY|Aug 6, 2026

This prospective study confirms that liver stiffness measurements by Fibroscan® strongly predict transplant-free survival in primary sclerosing cholangitis patients, validating both static values and dynamic changes as vital prognostic mark

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