Brain Natriuretic Peptide Levels as a Prognostic Biomarker After Pulmonary Endarterectomy in Chronic Thromboembolic Pulmonary Hypertension

Highlight

1. Elevated brain natriuretic peptide (BNP) plasma levels 3 to 6 months after pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are associated with a significantly increased risk of long-term cardiac mortality.
2. High-sensitivity troponin I (hs-TNI) adds limited incremental prognostic value beyond BNP in this patient population.
3. BNP provides prognostic information independent of, and additional to, measures of persistent pulmonary hypertension (PH) after surgery.
4. Assessment of BNP post-PEA can refine risk stratification and guide clinical management in CTEPH patients.

Study Background