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New A-TANGO Organ Failure Score Refines ACLF Diagnosis and Risk Stratification in Global Cohorts
Critical Carecirrhosisprognosis

New A-TANGO Organ Failure Score Refines ACLF Diagnosis and Risk Stratification in Global Cohorts

By MedXY|Jul 26, 2026

A new organ failure score, A-TANGO, improves ACLF diagnosis and risk stratification compared to standard CLIF-C criteria, validated in large international cohorts.

Measurable Residual Disease as a Prognostic Biomarker in Frontline Azacitidine and Venetoclax-Treated AML: Insights from the French VENAURA Registry
Hematology-Oncologyacute myeloid leukemia
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azacitidine

Measurable Residual Disease as a Prognostic Biomarker in Frontline Azacitidine and Venetoclax-Treated AML: Insights from the French VENAURA Registry

By MedXY|Jul 20, 2026

In AML patients receiving frontline azacitidine and venetoclax, achieving measurable residual disease negativity strongly predicts longer survival and lower relapse rates, overriding baseline risk factors, as shown in the French VENAURA reg

Molecular Mutations and Cardiovascular Risks Shape Prognosis in Triple-Negative Essential Thrombocythemia
Cardiologycardiovascular riskMutation profile

Molecular Mutations and Cardiovascular Risks Shape Prognosis in Triple-Negative Essential Thrombocythemia

By MedXY|Jul 15, 2026

This study reveals that specific gene mutations and cardiovascular risk factors significantly influence prognosis and thrombotic risk in triple-negative essential thrombocythemia, highlighting the importance of molecular profiling for perso

Impact of Diagnosis-to-Treatment Interval on Outcomes in Follicular Lymphoma Undergoing Immunochemotherapy
Hematology-Oncologydiagnosis-to-treatment intervalFollicular lymphoma

Impact of Diagnosis-to-Treatment Interval on Outcomes in Follicular Lymphoma Undergoing Immunochemotherapy

By MedXY|Jun 30, 2026

Shorter diagnosis-to-treatment intervals independently predict worse outcomes in follicular lymphoma treated with immunochemotherapy, highlighting a novel prognostic factor beyond existing risk indices.

Refining Prognostic Assessment in Perihilar Cholangiocarcinoma: The Clinical Utility of Dual Radial Margin Distance Cutoffs
General Surgeryperihilar cholangiocarcinomaprognosis

Refining Prognostic Assessment in Perihilar Cholangiocarcinoma: The Clinical Utility of Dual Radial Margin Distance Cutoffs

By MedXY|Jun 29, 2026

This study identifies dual cutoff values of 0 and 1 mm for radial margin distance in perihilar cholangiocarcinoma, providing a simple and effective stratification tool for postoperative recurrence risk and survival prediction.

Revisiting Level VII Lymph Node Metastasis in Medullary Thyroid Cancer: A Crucial Prognostic Subgroup
Diabetes & Endocrinologycancer stagingDi căn hạch cổ

Revisiting Level VII Lymph Node Metastasis in Medullary Thyroid Cancer: A Crucial Prognostic Subgroup

By MedXY|Jun 25, 2026

Level VII lymph node metastasis in medullary thyroid cancer signifies a highly aggressive phenotype with the poorest prognosis. Reclassifying level VII nodes as N1b improves prognostic accuracy and could refine staging and treatment strateg

Cancer and Heart Failure in Scotland: Epidemiology, Interactions, and Prognostic Implications
Cardiologycancerepidemiology

Cancer and Heart Failure in Scotland: Epidemiology, Interactions, and Prognostic Implications

By MedXY|Jun 24, 2026

This review synthesizes evidence on the prevalence, incidence, and prognosis of cancer and heart failure comorbidity in Scotland, integrating recent cohort data and cardio-oncology research to inform clinical practice and future research di

Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification
Clinical Updatesdd-cfDNAHeart Transplantation

Donor-Derived Cell-Free DNA as a Prognostic Biomarker in Severe Cardiac Allograft Rejection: From Detection to Risk Stratification

By MedXY|Jun 17, 2026

Recent heart-transplant studies show donor-derived cell-free DNA not only detects rejection but also predicts mortality and persistent graft dysfunction, especially when elevated at diagnosis. Evidence supports a shift from binary surveilla

Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma
Gastroenterologybilateral hepatocellular carcinomahepatectomy

Machine Learning Clustering Reveals Distinct Phenotypes in Bilateral Hepatocellular Carcinoma

By MedXY|Jun 4, 2026

Machine learning identified two distinct bilateral hepatocellular carcinoma phenotypes with different tumor burdens, surgical approaches, and outcomes, suggesting preoperative risk stratification may improve patient selection and treatment

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact
Hematology-Oncologycancer-related ischemic strokeCRIS

Application of the AHA-Proposed Cancer-Related Ischemic Stroke Classification: Reclassification and Prognostic Impact

By MedXY|Jun 3, 2026

The AHA-proposed CRIS classification reclassified many cancer-associated strokes previously labeled cryptogenic and identified a subgroup with markedly worse survival, improving both etiologic clarity and prognostic stratification.

Pathologic Myopia Globe Shape and Long-Term Prognosis
newseye shapehigh myopia

Pathologic Myopia Globe Shape and Long-Term Prognosis

By MedXY|Jun 1, 2026

Three-dimensional eye shape on MRI predicted 15-year outcomes in high myopia. Nasally distorted and conical eyes had the highest risk of rapid elongation, macular thinning, myopic degeneration, and visual field defects.

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms
Hematology-Oncologydel(5q)MDS

TP53 Multihit Does Not Fully Erase the Prognostic Advantage of Isolated del(5q) in Myelodysplastic Neoplasms

By MedXY|May 9, 2026

A multicenter retrospective study suggests that MDS with isolated del(5q) and TP53 multihit alterations has substantially better survival than other low-blast TP53-multihit MDS, challenging how this subgroup should be classified.

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study
Internal MedicineCOPDexacerbations

Mild and Single Moderate COPD Exacerbations Predict Future Risks: Insights from a Community-Based Cohort Study

By MedXY|Apr 27, 2026

Community-based COPD patients with mild or single moderate exacerbations show higher future exacerbation risks and lung structural abnormalities, despite stable lung function decline rates.

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses
Clinical UpdatesCerebral Venous ThrombosisInflammatory Biomarkers

Inflammatory Biomarkers in Cerebral Venous Thrombosis: Prognostic Insights from the CLOT-VENUS Substudy and Meta-Analyses

By MedXY|Apr 22, 2026

High admission levels of NLR, PLR, MLR, and SII are independently associated with poor functional outcomes and mortality in acute cerebral venous thrombosis, offering a low-cost tool for early risk stratification.

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy
CardiologyGDMTheart failure

Right Ventricular to Pulmonary Artery Coupling: A New Prognostic Marker in Heart Failure Therapy

By MedXY|Apr 22, 2026

A study reveals that RV-PA coupling, measured by TAPSE/sPAP ratio, significantly predicts outcomes in HFrEF patients during GDMT up-titration, highlighting its potential as a treatment target.

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy
Gastroenterologyfusion modelhepatocellular carcinoma

Novel Fusion Model Combines Hypoxia and Immune Signatures to Predict Survival in HCC Patients Undergoing TACE Therapy

By MedXY|Apr 2, 2026

A groundbreaking multicentre study develops a clinical-radiologic model integrating hypoxia and immune phenotype signatures to accurately predict prognosis in hepatocellular carcinoma patients treated with transarterial chemoembolisation, p

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis
Cardiologyechocardiographyheart failure

Beyond the Restrictive Paradigm: Redefining Left Ventricular Phenotypes and Prognosis in Cardiac Amyloidosis

By MedXY|Mar 2, 2026

A large-scale retrospective study challenges the classic view of cardiac amyloidosis, revealing that while restriction is the dominant phenotype at diagnosis, nearly one-third of patients present with preserved function, and progression pat

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia
Neurologyprognosistransient ischemic attack

Post-TIA Depression: A Silent Predictor of Mortality and Long-Term Disability Independent of Brain Ischemia

By MedXY|Jan 7, 2026

A population-based study reveals that nearly one-quarter of TIA patients experience depression, which significantly increases the risk of mortality and disability, regardless of whether acute ischemic lesions are present on imaging.

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial
CardiologyGALACTIC-HFheart failure

Hypermagnesemia as a Potent Predictor of Adverse Outcomes in Heart Failure: New Evidence from the GALACTIC-HF Trial

By MedXY|Jan 1, 2026

A secondary analysis of the GALACTIC-HF trial demonstrates that hypermagnesemia, rather than hypomagnesemia, is significantly associated with increased cardiovascular death and worsening heart failure in patients with HFrEF, challenging cur

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis
newsEndometrial Cancerprognosis

Cervical Stromal Invasion Does Not Independently Predict Survival in Early-Stage Endometrial Cancer: A Multicenter Analysis

By MedXY|Dec 25, 2025

A large-scale multicenter study indicates that cervical stromal invasion is not an independent prognostic factor for survival in early-stage endometrial cancer, challenging traditional staging assumptions when other high-risk features are c

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