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Oxidized Phospholipid PGPC Impedes Angiogenesis by Disrupting Endothelial Autophagy via NPC1-Mediated Syntaxin 17 Modification
Cardiologyangiogenesisautophagy

Oxidized Phospholipid PGPC Impedes Angiogenesis by Disrupting Endothelial Autophagy via NPC1-Mediated Syntaxin 17 Modification

By MedXY|Oct 10, 2026

The oxidized phospholipid PGPC inhibits angiogenesis in ischemic heart disease by impairing endothelial autophagic flux through NPC1-induced acetylation and ubiquitination of syntaxin 17, unveiling new potential therapeutic targets for coro

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