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Laminopathies: Natural History and Risk Prediction of Heart Failure

By MedXY|Jun 26, 2026

This review synthesizes recent advances in understanding the natural history of LMNA-related cardiomyopathies and introduces the first validated prediction model for severe heart failure events, enhancing early risk stratification and manag

CardiologyCardiac ArrhythmiaEmery-Dreifuss Muscular Dystrophy

LMNA

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Laminopathies: Natural History and Risk Prediction of Heart Failure

Breakthrough Study Reveals WNT5a-Driven Actin Dysregulation as Core Mechanism in LMNA-Related Cardiac Disease

LMNA Variant Type and Location Shape Arrhythmic Risk in Cardiomyopathy: Truncations Confer Higher VA Risk; Tail-domain Missense Variants Appear Lower Risk