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Genotype-Dependent Risk and Impact of Atrial Fibrillation in Dilated Cardiomyopathy: Insights from the SHaRe Registry
CardiologyLMNAgenetics

Genotype-Dependent Risk and Impact of Atrial Fibrillation in Dilated Cardiomyopathy: Insights from the SHaRe Registry

By MedXY|Sep 15, 2026

This study reveals genotype-specific differences in atrial fibrillation (AF) risk among dilated cardiomyopathy (DCM) patients, highlighting LMNA mutations as a major predictor of incident AF and its association with worse clinical outcomes,

Laminopathies: Natural History and Risk Prediction of Heart Failure
Clinical Updatesheart failurelaminopathies

Laminopathies: Natural History and Risk Prediction of Heart Failure

By MedXY|Jun 26, 2026

This review synthesizes recent advances in understanding the natural history of LMNA-related cardiomyopathies and introduces the first validated prediction model for severe heart failure events, enhancing early risk stratification and manag

Breakthrough Study Reveals WNT5a-Driven Actin Dysregulation as Core Mechanism in LMNA-Related Cardiac Disease
CardiologyCardiac ArrhythmiaEmery-Dreifuss Muscular Dystrophy

Breakthrough Study Reveals WNT5a-Driven Actin Dysregulation as Core Mechanism in LMNA-Related Cardiac Disease

By MedXY|Apr 18, 2026

This groundbreaking research identifies WNT5a-mediated aberrant actin filament dynamics as the novel mechanism driving cardiac pathogenic phenotypes in Emery-Dreifuss muscular dystrophy, opening new therapeutic avenues for this rare but dev

LMNA Variant Type and Location Shape Arrhythmic Risk in Cardiomyopathy: Truncations Confer Higher VA Risk; Tail-domain Missense Variants Appear Lower Risk
Cardiologyarrhythmiacardiomyopathy

LMNA Variant Type and Location Shape Arrhythmic Risk in Cardiomyopathy: Truncations Confer Higher VA Risk; Tail-domain Missense Variants Appear Lower Risk

By MedXY|Dec 3, 2025

In 718 patients with pathogenic/likely pathogenic LMNA variants, truncating variants carried higher risk of malignant ventricular arrhythmia independent of position, while missense variants in the tail domain and exons 7–12 had lower arrhyt

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