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Decoding the Genomic and Clinical Impact of RAS Mutations in Acute Myeloid Leukemia
Hematology-Oncologyprognostic biomarkersKRAS

Decoding the Genomic and Clinical Impact of RAS Mutations in Acute Myeloid Leukemia

By MedXY|Oct 22, 2026

This comprehensive analysis of 8,553 AML patients reveals diverse RAS mutation patterns, their associations with other genomic alterations, and distinct prognostic implications influenced by the genomic context and treatment modalities, gui

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma
GastroenterologygastroenterologyKRAS

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma

By MedXY|Jul 8, 2026

This study reveals that dysregulated sphingolipid metabolism via SMPD1 supports KRAS-driven pancreatic cancer progression, identifying SMPD1 as a promising therapeutic target in pancreatic ductal adenocarcinoma.

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