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This pooled analysis of seven multi-ethnic cohorts demonstrates the combined prognostic value of plasma phosphorylated tau 217 concentrations and APOE-ε4 genotype for predicting risk and timing of cognitive impairment, emphasizing biomarker
A single-center cross-sectional study found that iatrogenic cerebral amyloid angiopathy carries a higher amyloid PET burden, weaker CSF-PET coupling, and less APOE ε4 enrichment than sporadic disease, supporting a biologically distinct mech
Recent advances in digital pathology and machine learning reveal that APOE ε4 promotes proteinopathy and modifies dementia thresholds, while multi-modal trajectories suggest distinct pathways for disease progression in Lewy body disease.