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Decoding Systemic Inflammation in Long COVID and Autoimmune Diseases: The Role of Intestinal Flagellin and the TLR5-IL-15-ARA Axis
GastroenterologyIL-15全身炎症

Decoding Systemic Inflammation in Long COVID and Autoimmune Diseases: The Role of Intestinal Flagellin and the TLR5-IL-15-ARA Axis

By MedXY|Aug 22, 2026

This article explores how intestinal flagellin drives systemic inflammation via the TLR5-IL-15-ARA pathway in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD, highlighting potential therapeutic targets and biomarkers.

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway
GastroenterologyIL-15
全身炎症

Unraveling the Gut-Lung Axis: Intestinal Flagellin as a Driver of Multisystem Inflammation via the TLR5-IL-15-ARA Pathway

By MedXY|Aug 21, 2026

Flagellated gut bacteria activate TLR5 on neutrophils, triggering IL-15 release and macrophage arachidonic acid production, driving systemic inflammation in long COVID, rheumatoid arthritis, ankylosing spondylitis, and IBD.

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