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Targeting IMPDH2-Induced Guanine Nucleotide Depletion to Enhance KRAS Inhibition in Pancreatic Cancer
GastroenterologyIMPDH2Guanine Nucleotide Depletion

Targeting IMPDH2-Induced Guanine Nucleotide Depletion to Enhance KRAS Inhibition in Pancreatic Cancer

By MedXY|Oct 17, 2026

An integrated genomic and pharmacologic analysis identifies IMPDH2 as a key vulnerability in KRAS-mutant pancreatic cancer, showing that irreversible guanine nucleotide depletion potentiates KRAS-targeted therapies and offers a novel combin

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