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MedXY AI/MedXY News/Tag: distant disease-free survival
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Adjuvant Radiotherapy Reduces Recurrence After Complete Resection of WHO Grade 2 Atypical Meningioma: Insights from the ROAM/EORTC-1308 Phase 3 Trial
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Adjuvant Radiotherapy Reduces Recurrence After Complete Resection of WHO Grade 2 Atypical Meningioma: Insights from the ROAM/EORTC-1308 Phase 3 Trial

By MedXY|Oct 16, 2026

The ROAM/EORTC-1308 trial demonstrates that adjuvant radiotherapy after complete surgical resection of atypical meningioma significantly improves 5-year disease-free survival, reducing recurrence risk with manageable adverse effects.

Distant Disease‑Free Survival Is a Reliable Surrogate for Overall Survival in Most Neoadjuvant Early Breast Cancer Trials — but Not All Subtypes
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Distant Disease‑Free Survival Is a Reliable Surrogate for Overall Survival in Most Neoadjuvant Early Breast Cancer Trials — but Not All Subtypes

By MedXY|Nov 30, 2025

A pooled individual‑patient analysis of 11 neoadjuvant RCTs (12,247 patients) finds distant disease‑free survival (DDFS) strongly predicts overall survival (OS) trial‑level effects overall (R2trial=0.91), with weakened surrogacy in hormone‑

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