Chronic Limb-Threatening Ischemia

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CardiologyChronic Limb-Threatening Ischemiagene therapy

Anatomically Directed HGF Gene Therapy Significantly Accelerates Ulcer Healing in Chronic Limb-Threatening Ischemia: Insights from the LEGenD-1 Trial

By MedXY|Feb 4, 2026

The LEGenD-1 trial demonstrates that intramuscular HGF gene therapy (AMG0001) significantly reduces healing time for neuroischemic ulcers in patients with moderate chronic limb-threatening ischemia, offering a potential nonsurgical therapeu

Atherectomy Fails to Improve Limb-Based Outcomes in Chronic Limb-Threatening Ischemia: A Critical Analysis of the BEST-CLI Trial

CardiologyChronic Limb-Threatening Ischemia

Chronic Limb-Threatening Ischemia

Latest news

Anatomically Directed HGF Gene Therapy Significantly Accelerates Ulcer Healing in Chronic Limb-Threatening Ischemia: Insights from the LEGenD-1 Trial

Atherectomy Fails to Improve Limb-Based Outcomes in Chronic Limb-Threatening Ischemia: A Critical Analysis of the BEST-CLI Trial