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CardiologyCD38vascular ageing

METTL14 and LATS1/2 Define Divergent Endothelial Programs That Drive Vascular Ageing and Atherothrombosis — New Therapeutic Nodes in Cardio‑Vascular Senescence

By MedXY|Dec 2, 2025

Two complementary studies identify METTL14/TLR4 and LATS1/2–CD38–SUOX axes as key drivers of endothelial senescence phenotypes that promote arterial ageing, stiffness, fragile neovessels and atherothrombotic plaque formation, highlighting n

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biomarkers

CD38

Decoding Response-Adapted Daratumumab Therapy in Elderly Multiple Myeloma: Biomarkers and Mechanisms of Sensitivity and Resistance

By MedXY|Oct 14, 2025

A response-adapted trial of daratumumab monotherapy in elderly newly diagnosed multiple myeloma reveals key biomarkers—CD38 expression, plasma cell phenotype, and immune microenvironment—that predict treatment sensitivity and inform therape

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