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When Language Becomes a Safety Risk: English Proficiency and Hospital Restraint Practices
Internal Medicineantipsychoticsdelirium

When Language Becomes a Safety Risk: English Proficiency and Hospital Restraint Practices

By MedXY|Jun 19, 2026

A large single-center study found that hospitalized patients with limited English proficiency had higher adjusted odds of physical restraint or antipsychotic use, especially when delirium was present, raising concerns about communication-dr

Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial
Diabetes & Endocrinology
antipsychotics
insulin sensitivity

Semaglutide Improves Insulin Sensitivity in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial

By MedXY|May 26, 2026

In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antip

Antipsychotic Exposure in the ICU: A Double-Edged Sword for Catatonia Risk?
Critical CareantipsychoticsCatatonia

Antipsychotic Exposure in the ICU: A Double-Edged Sword for Catatonia Risk?

By MedXY|Mar 14, 2026

A prospective cohort study demonstrates that antipsychotic use in critically ill patients is significantly associated with fewer catatonia-free days, suggesting that dopamine blockade may be a primary driver of catatonic syndromes in intens

Comparative Efficacy and the Muscarinic Breakthrough: A Comprehensive Network Meta-Analysis of Antipsychotic Interventions for Acute Schizophrenia
newsantipsychoticsmeta-analysis

Comparative Efficacy and the Muscarinic Breakthrough: A Comprehensive Network Meta-Analysis of Antipsychotic Interventions for Acute Schizophrenia

By MedXY|Mar 6, 2026

This landmark network meta-analysis of 438 RCTs evaluates 24 antipsychotics, revealing clozapine as the most effective while highlighting the novel muscarinic agonist xanomeline-trospium. The study emphasizes clinically relevant efficacy di

Beyond Dopamine Blocking: Network Meta-Analysis Redefines Efficacy and Tolerability Hierarchies in Acute Schizophrenia
newsantipsychoticsNetwork meta-analysis

Beyond Dopamine Blocking: Network Meta-Analysis Redefines Efficacy and Tolerability Hierarchies in Acute Schizophrenia

By MedXY|Mar 6, 2026

A landmark network meta- **Developing Article Components** I’m now diving deep into the content, focusing on fleshing out each section. The Highlight section’s first drafts are complete. I’m incorporating the study’s

Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety
newsantipsychoticsclozapine

Clozapine Works Beyond Schizophrenia: Nationwide Evidence for Transdiagnostic Effectiveness and Safety

By MedXY|Dec 1, 2025

Large Finnish and Swedish registry cohorts show clozapine is associated with lower psychiatric hospitalisation across schizophrenia-spectrum, bipolar disorder and severe depression without increased overall mortality or hospitalisation.

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial
newsantipsychoticsefficacy

Comparative Efficacy and Tolerability of Seven Antipsychotics in Acute Schizophrenia: Insights from a Large Multicenter Randomized Trial

By MedXY|Oct 29, 2025

A multicenter randomized trial comparing seven antipsychotics in acute schizophrenia shows olanzapine and risperidone outperform several agents in efficacy but differ markedly in side effects, clarifying treatment choices.

Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study
Internal Medicineadverse eventsantipsychotics

Comparative Effectiveness of Long-Acting Injectable Versus Oral Antipsychotics in Older Adults with Schizophrenia: Insights from Hong Kong’s Population-Based Study

By MedXY|Oct 18, 2025

This study compares long-acting injectable to oral antipsychotics in older schizophrenia patients, highlighting benefits in relapse prevention and mortality reduction, with specific considerations for adverse effects.

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission
Clinical Updatesantipsychoticsdose reduction

Balancing Risks and Benefits: Early Antipsychotic Dose Reduction Versus Maintenance After First-Episode Psychosis Remission

By MedXY|Oct 6, 2025

A randomized clinical trial reveals early dose reduction of antipsychotics after first-episode psychosis remission increases short-term relapse risk and lowers quality of life, but may improve long-term functioning over four years.

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