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Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

By MedXY|Jun 10, 2026

ORBITA-FIRE shows that angina occurs at much lower, individualized FFR and RFR thresholds than standard ischemia cutoffs, and these thresholds rise with exercise intensity.

Cardiology

angina

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Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

Determining the Physiological Threshold for Angina (ORBITA-FIRE): A Double-Blind, Randomized, Placebo-Controlled Study

Quality of Life After Percutaneous Coronary Intervention or Medical Therapy for Chronic Total Coronary Occlusions: EUROCTO and DECISION-CTO Meta-Analysis

Persistent Healthcare Burden in Women with Chest Pain Despite No Obstructive Coronary Artery Disease: Insights from the WOMANOCA Study

Aetiology-Guided (Stratified) Care Improves Angina in MINOCA: Key Findings from the PROMISE Trial

Routine Coronary Function Testing in ANOCA Improves Symptoms: Key Results from the ILIAS ANOCA Trial

Endotyping-informed CMR-guided care markedly improves angina and quality of life in patients with chest pain and no obstructive CAD