Oncology
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Validated IMPACT Tool Enables Risk‑Stratified Outpatient Management of Incidental Meningioma
A large international cohort externally validated the IMPACT clinical tool, demonstrating accurate prediction of incidental meningioma progression and supporting triage to early intervention, serial monitoring, or safe discharge.
Metformin Fails to Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obese Men
The MAST phase III trial found no benefit of metformin (850 mg twice daily) versus placebo for delaying progression in men with low‑risk prostate cancer on active surveillance; a prespecified subgroup showed increased pathologic progression
Metformin Does Not Delay Progression on Active Surveillance for Low‑Risk Prostate Cancer — Unexpected Signal in Obesity
A randomized phase III trial (MAST) found metformin did not prolong progression‑free survival in men on active surveillance for low‑risk prostate cancer; an exploratory subgroup showed increased pathologic progression in obese patients.
Preoperative Clues That Predict Who Will Receive Adjuvant Therapy After Surgery for Oral Cavity Cancer
In a multicenter cohort of 3,980 oral cavity squamous cell carcinoma patients, preoperative clinical and tumor features—including age, comorbidity, tumor subsite, size, clinical stage, and biopsy grade—predicted receipt and intensity of adj
Clinical Benefit—not Billing Margin—Drives Oncologists’ Treatment Choices in Medicare Cohort
In a population-based Medicare cohort, oncologists preferentially selected higher-clinical-benefit cancer treatments; provider billing margin was not associated with treatment choice, suggesting price or payment reforms that change margins
HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States
A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.041 (
Adjuvant Chemoradiotherapy Helps Patients with Major — Not Minor — Extranodal Extension in Oral Cavity SCC
A multicenter cohort study shows adjuvant chemoradiotherapy improves disease-free and overall survival for oral cavity SCC patients with major extranodal extension (>2 mm) but provides no clear benefit for those with minor ENE (≤2 mm).
HPV-Positive Oropharyngeal Cancer Retains a Strong Survival Advantage After Surgery in Patients Aged ≥70
In a multi-center cohort of 345 surgically treated patients aged 70 or older with tonsil or base‑of‑tongue SCC, p16 positivity was associated with substantially better 5‑year overall and disease‑free survival compared with p16‑negative tumo
Doublet Chemotherapy Plus EGFR/BRAF Targeting Yields Best Survival in Advanced BRAF‑Mutated Colorectal Cancer: A 4,633‑Patient Network Meta‑Analysis
A BMJ systematic review and network meta‑analysis of 60 studies (4,633 patients) finds doublet chemotherapy combined with anti‑EGFR/BRAF therapy offers the best first‑line overall survival for advanced BRAF‑mutant colorectal cancer; anti‑EG
Unilateral TORS for HPV-Positive Tonsillar Cancer Appears Safe — Bilateral Contralateral Tonsillectomy May Add Harm Without Clear Benefit
In a retrospective cohort of 158 HPV-positive tonsil SCC patients, omission of prophylactic contralateral tonsillectomy during TORS was not associated with worse survival and showed trends toward fewer hemorrhages, ED visits, and shorter ho
Proton Beam vs IMRT for Olfactory Neuroblastoma: Multicenter Propensity-Matched Cohort Shows No Clear Superiority
A multicenter propensity-matched cohort comparing adjuvant proton beam radiotherapy (PBRT) with intensity-modulated radiotherapy (IMRT) for olfactory neuroblastoma found no definitive differences in local control, recurrence-free survival,
Pathologic Response to Neoadjuvant Nivolumab Predicts Improved Survival in HPV‑Negative Head and Neck Cancer
A pooled analysis of two neoadjuvant nivolumab trials found that pathologic treatment effect >57% is associated with markedly improved 3‑year disease‑free and overall survival in HPV‑negative resectable HNSCC, suggesting pTE may be a useful
Radiotherapy for Growing Vestibular Schwannomas: Real‑World Tumor Control and What It Means for Practice
An international multicenter cohort of 1,883 patients with radiologically growing vestibular schwannomas treated first‑line with radiotherapy showed a 10‑year tumor control rate of 76.1% (primary definition). Control estimates varied widely
Palliative Care Timing, Tracheostomy, and Gastrostomy in Head and Neck Cancer: Implications for End-of-Life Quality and Costs
Early palliative care may reduce healthcare costs in head and neck cancer patients using tracheostomy or gastrostomy tubes but does not lessen aggressive hospital care or promote home deaths at the end of life.
Palliative Care, Tracheostomy and Gastrostomy Tube Use, and End-of-Life Outcomes in Head and Neck Cancer: A Comprehensive Review
This review synthesizes evidence on the timing of palliative care and the use of tracheostomy/gastrostomy tubes in head and neck cancer patients, highlighting their impact on end-of-life costs, quality, and care settings.
Proton Beam vs IMRT for Olfactory Neuroblastoma: Too Little Data for a Definitive Answer — What the New Propensity-Matched Cohort Tells Us
A multi-institutional propensity-matched cohort found no definitive differences in oncologic outcomes or grade ≥2 radiotherapy toxicities between adjuvant proton beam radiotherapy and IMRT for olfactory neuroblastoma, but estimates were imp
Antibody–Drug Conjugates and Heart Risk in HER2-Positive Advanced Breast Cancer: What Clinicians Need to Know
A 2025 meta-analysis of 9,538 patients found trastuzumab emtansine (T‑DM1) carries the lowest incidence of LVEF decline (0.94%), while trastuzumab deruxtecan (T‑DXd) and trastuzumab-based combinations show similar, modest rates (≈4–5%). Tri
Therapist-Guided e‑Health Cuts Fear of Cancer Recurrence in Colorectal Survivors: A Randomized Trial Shows Clinically Meaningful Benefits
A Danish RCT of TG‑iConquerFear, a 10‑week therapist‑guided online program for colorectal cancer survivors with clinical fear of cancer recurrence (FCR), reduced FCR scores substantially compared with augmented self‑help at 3 months; the be
Preoperative Single‑Fraction Ablative Radiotherapy for Early HR+ Breast Cancer: Low Toxicity, High Pathologic Responses with Delayed Surgery
A phase 1 trial reports tolerable single‑fraction preoperative stereotactic partial‑breast irradiation (30–38 Gy) with low toxicity, preserved cosmesis, and high pathologic complete response rates when surgery was delayed beyond ~9 months o
Neural Networks Predict Survival for Older Adults With Head and Neck Cancer — Useful, but Not Yet Practice-Changing
An international cohort study developed and externally validated artificial neural networks that stratify older adults with locoregionally advanced head and neck squamous cell carcinoma (HNSCC) treated with definitive chemoradiation. Models
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