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This retrospective study found that immune checkpoint inhibitors produced modest overall benefit in recurrent vulvar and vaginal carcinoma, but a small subset of patients had durable responses lasting months.
A nationwide French study found that hospitals performing at least 40 posterior deep infiltrating endometriosis surgeries per year had fewer severe postoperative complications, supporting referral to experienced, high-volume centers.
A large U.S. cohort study found higher rates of postpartum psychiatric conditions after planned or unplanned cesarean delivery, but not after successful operative vaginal delivery, highlighting the need for closer postpartum mental health f
A prespecified CIRCUIT analysis found that Control-IQ closed-loop insulin delivery improved intrapartum time in range and reduced early postpartum hypoglycemia versus standard care in women with type 1 diabetes, without new safety concerns.
Higher proteinuria in preeclampsia was linked to greater long-term risk of maternal hypertension and chronic kidney disease, with overall increased risk of cardiovascular disease as well.
In TTTS, a post hoc analysis found that treating vein-to-vein placental connections at the end of fetoscopic laser surgery was linked to worse donor and recipient survival than earlier treatment.
Higher insulin resistance before pregnancy was linked to poorer ovulation, lower pregnancy and live-birth rates, and more gestational diabetes in women with PCOS. Improving insulin resistance during treatment was associated with better preg
In women with chronic severe coronary artery disease, CABG was linked to lower long-term rates of death, stroke, heart attack, repeat revascularization, and cardiovascular readmission than PCI.
Pembrolizumab plus chemoradiotherapy improved survival and quality-adjusted survival for FIGO 2014 stage III-IVA cervical cancer and was projected to be cost-effective in the U.S. at a $150,000/QALY threshold.
This study links PCOS-related miscarriage risk to gut microbiome changes, especially reduced Parabacteroides merdae and higher isoleucine, which may promote endometrial senescence and impair pregnancy outcomes.
Hospitals that serve more Black patients had higher rates of trial of labor after cesarean and VBAC success among low-risk patients, suggesting hospital practices may influence cesarean-related disparities.
A Danish multicenter study found that adding HE4 to the IOTA ADNEX model offered only limited, threshold-dependent benefit for assessing adnexal masses, with no meaningful improvement in non-tertiary centers.
A randomized trial found vaginal assisted NOTES hysterectomy improved same-day discharge, operative time, and blood loss versus standard vaginal hysterectomy, without increasing complications or affecting recovery.
A U.S. national study found endometriosis surgery is shifting from inpatient to outpatient care, with hospital cases more common in older, medically complex patients and those with more extensive disease.
Severe surgical complications during cesarean delivery were linked to about twice the risk of postpartum readmission within 42 days, especially for wound infection, supporting closer follow-up after complicated births.
A large real-world registry study shows that ovarian cancer patients aged 70 and older still carry clinically actionable germline variants, often without a reported family history, supporting broader age-inclusive genetic testing.
A large Australian longitudinal study found that women with both hot flushes and night sweats had slightly higher odds of retirement, suggesting menopausal symptom burden may influence workforce participation.
This review synthesizes contemporary evidence on the duration of active pushing, highlighting how epidural use, fetal malposition, and parity influence the probability of spontaneous delivery and maternal-neonatal outcomes.
A randomized trial found that 6 hours of intrauterine balloon tamponade was noninferior to 18 hours for controlling postpartum hemorrhage after vaginal delivery, suggesting earlier removal may be reasonable in stable patients.
A clinical trial found that weekly extended-release buprenorphine significantly improves illicit opioid abstinence during pregnancy compared to sublingual forms, with fewer serious adverse events, offering a safer treatment option for opioi
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