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The PreMeFen trial found inhalational methoxyflurane provided rapid, clinically meaningful pain relief at 10 minutes and was non-inferior to intranasal fentanyl and intravenous morphine in the prehospital setting, offering a practical non‑i
The RAFF4 randomized trial found intravenous vernakalant superior to procainamide for rapid cardioversion of acute atrial fibrillation in the emergency department — higher conversion within 30 minutes, faster time to sinus rhythm, and fewer
A 2025 systematic review and meta-analysis found that endurance exercise in the heat increases carbohydrate oxidation and muscle glycogen use; dehydration amplifies this effect principally when combined with heat. Findings inform fueling an
A large multicenter trial demonstrated that deferring early arterial catheter insertion in ICU patients with shock is noninferior to early invasive monitoring for 28-day mortality, with fewer catheter-related complications and comparable sa
AEDs improve survival in in-home cardiac arrests with shockable rhythms but are not cost-effective for widespread private home use at current prices and incidence rates, per a large US cohort study using CARES data.
Venomous snakes cause thousands of bites annually in the US, with serious health consequences. Understanding snake types, symptoms, first aid, and prevention can save lives.
Prompt opioid delivery in pediatric EDs for sickle cell pain significantly lowers hospitalization rates, with the greatest benefit seen when the first dose is given within 60 minutes and the second dose within 30 minutes.
This study evaluates factors influencing vasopressor route choice in sepsis and demonstrates low complication rates associated with peripheral administration, supporting its safety in early resuscitation.
Comparative effectiveness evidence from multicenter pediatric emergency departments demonstrates that targeted and universally offered gonorrhea and chlamydia screening increase detection rates versus usual care, highlighting the need for i
Antiviral prescriptions for children at high risk of severe influenza in US pediatric emergency departments decreased by over 50% during the COVID-19 pandemic compared with prepandemic rates, despite unchanged treatment guidelines.
This article reviews injury profiles from animal bites, emphasizing plastic surgery roles, treatment strategies, and a predictive model for complications, based on a large clinical dataset from Balıkesir University.
A large multicenter study finds no association between fentanyl administration and failed reduction of pediatric ileocolic intussusception, supporting its safe use for analgesia during the painful reduction procedure.
Telestroke evaluation increases thrombolysis rates but is associated with longer treatment times and delays in patient transfers in acute ischemic stroke, highlighting the need to address modifiable treatment delays.
This study developed and validated machine learning models with high accuracy to predict early pediatric sepsis and septic shock within 48 hours using multisite electronic health record data in emergency departments.
This qualitative UK study explores older patients’ perspectives on shared decision making for treatment escalation during acute hospital deterioration, highlighting the need for patient autonomy, education, and adaptable clinical appr
A randomized clinical trial demonstrates that a novel avalanche safety device delaying hypoxia and hypercapnia can extend survival time beyond the critical 35-minute asphyxiation window during avalanche burial.
A systematic synthesis of clinical practice guideline recommendations for preventing and managing mental disorders after traumatic injury, with prioritized, implementable actions for acute and early recovery care.
Delayed cannabis test results in children under 6 with poisoning symptoms prolong ED visits and influence neuroimaging use. Faster toxicology screening could optimize care and reduce unnecessary scans.
Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and CNS dysfunction, necessitating rapid recognition and intervention to prevent multi-organ failure and death. This article reviews its pathophysiol
The Best Case/Worst Case-ICU communication tool supports trauma ICU teams in effectively discussing prognoses with families, improving decision-making and reducing distress, though implementation faces practical barriers.
