
医学资讯CCL2NSUN6
靶向NSUN6缺失逆转胰腺癌免疫抑制:聚焦KDM5A-CCL2-巨噬细胞轴
By MedXY|2026年8月27日
胰腺癌中NSUN6缺失可通过KDM5A-CCL2轴增强免疫抑制性巨噬细胞浸润,促进免疫抑制并导致对免疫检查点阻断耐药;靶向该通路可能是一种有前景的治疗策略。
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