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Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

Hospital-Acquired DRESS and Clinical Severity Strongly Predict ICU Admission in a 39-Centre Paris Cohort

In this multicentre cohort of 207 hospitalized adults with DRESS, 17% required ICU care. Hospital-acquired DRESS and greater clinical severity independently predicted ICU admission, while ICU mortality reached 20%.

Section: Critical CareMay 28, 2026

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

Validated EMPEROR-Preserved Risk Models Stratify Prognosis in FINEARTS-HF, While Finerenone Benefits Remain Consistent Across Baseline Risk

In FINEARTS-HF, EMPEROR-Preserved biomarker-based risk models showed good prognostic discrimination in HFmrEF/HFpEF, and finerenone’s relative treatment effect was consistent across the full baseline risk spectrum.

Section: CardiologyMay 19, 2026

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

Associations of the Composite Pulmonary Embolism Shock Score in the Emergency Department With Short-Term Clinical Outcomes

A multicenter emergency department study found that CPES performed similarly to sPESI and ESC for short-term PE outcomes, but it better predicted the need for advanced intervention.

Section: CardiologyMay 19, 2026

2/20/20 Model Outperforms AQUILA Criteria in Identifying High-Risk Smoldering Multiple Myeloma

2/20/20 Model Outperforms AQUILA Criteria in Identifying High-Risk Smoldering Multiple Myeloma

The 2/20/20 risk stratification model identifies a smaller, truly high-risk SMM group with higher progression rates than the AQUILA trial criteria, suggesting better targeting for early intervention.

Section: Hematology-OncologyApr 24, 2026

RAI Outperforms mFI-5 in Predicting Post-UPPP Complications: A Frailty Stratification Breakthrough

RAI Outperforms mFI-5 in Predicting Post-UPPP Complications: A Frailty Stratification Breakthrough

The Risk Analysis Index (RAI) significantly outperforms the modified frailty index-5 (mFI-5) in predicting mortality and major complications after uvulopalatopharyngoplasty, supporting its adoption for preoperative risk assessment in sleep

Section: AnesthesiologyApr 24, 2026

A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models

A New Framework to Refine Hepatocellular Cancer Surveillance with Risk Stratification Models

The Translational Liver Cancer Consortium proposes a structured framework for developing and validating risk models to optimize HCC surveillance, addressing gaps in current clinical guidelines.

Section: GastroenterologyApr 23, 2026

Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma

Validation of the 2025 ATA Risk Stratification System in a Cohort of Patients with Papillary Thyroid Carcinoma

A real-world study validates the 2025 ATA thyroid cancer risk guidelines, showing significant patient reclassification and identifying a new ‘low-intermediate-risk’ group needing tailored management approaches.

Section: Diabetes & EndocrinologyApr 19, 2026

2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts

2025 ATA Risk Stratification for Papillary Thyroid Cancer: Validation Study Reveals Significant Reclassification Shifts

A retrospective study of 670 papillary thyroid carcinoma patients validates the 2025 ATA risk stratification system, demonstrating a shift toward higher-risk classifications. The new ‘low-intermediate-risk’ class emerges as a distinct entit

Section: Diabetes & EndocrinologyApr 19, 2026

Exercise Unmasks Multi-Organ Deficits That Predict Heart Failure Risk: Metabolite Signatures Reveal Shared Pathways Across HFpEF and Its Comorbidities

Exercise Unmasks Multi-Organ Deficits That Predict Heart Failure Risk: Metabolite Signatures Reveal Shared Pathways Across HFpEF and Its Comorbidities

A landmark study reveals that exercise-induced multi-organ physiologic deficits strongly predict incident heart failure with preserved ejection fraction (HFpEF). Using invasive cardiopulmonary testing, metabolomics, and genomics across over

Section: CardiologyApr 15, 2026

New EHR-Based Model PRIME Achieves 0.75 AUC in Predicting Pancreatic Cancer Risk Across 11 Million Patients

New EHR-Based Model PRIME Achieves 0.75 AUC in Predicting Pancreatic Cancer Risk Across 11 Million Patients

Researchers developed PRIME, a parsimonious risk stratification model for pancreatic ductal adenocarcinoma using electronic health record data. Validated across US health systems and the UK Biobank, PRIME retained 19 predictors and achieved

Section: GastroenterologyApr 7, 2026

Beyond Binary: A 4-Stage Risk Stratification Tool Transforms Cochlear Implant Candidacy Assessment

Beyond Binary: A 4-Stage Risk Stratification Tool Transforms Cochlear Implant Candidacy Assessment

Researchers developed a novel 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood, moving beyond traditional binary screening approaches to support personalized shared decision-maki

Section: newsApr 3, 2026

Sex-Specific Risk Thresholds in Aortic Regurgitation: Challenging the One-Size-Fits-All Approach to LV Remodeling

Sex-Specific Risk Thresholds in Aortic Regurgitation: Challenging the One-Size-Fits-All Approach to LV Remodeling

A multicenter study reveals that women with moderate-severe aortic regurgitation face higher mortality risk at lower ventricular volumes than men. Findings suggest current guidelines may require revision to include sex-specific volumetric t

Section: CardiologyMar 26, 2026

Stratifying Risk in Incidentally Detected Splenomegaly: Quantitative Thresholds for Hematologic and Hepatic Surveillance

Stratifying Risk in Incidentally Detected Splenomegaly: Quantitative Thresholds for Hematologic and Hepatic Surveillance

This review synthesizes large-scale cohort data defining specific spleen length and volume thresholds that significantly increase the 5-year absolute risk of hematologic cancers and chronic liver disease.

Section: Clinical UpdatesMar 23, 2026

Refining ARVC Risk Stratification: Does Left Ventricular Late Gadolinium Enhancement Add Incremental Value to Clinical Risk Calculators?

Refining ARVC Risk Stratification: Does Left Ventricular Late Gadolinium Enhancement Add Incremental Value to Clinical Risk Calculators?

A multi-center study of 385 ARVC patients reveals that while Left Ventricular Late Gadolinium Enhancement (LV LGE) correlates with ventricular arrhythmias, it fails to provide incremental prognostic value beyond the established ARVC risk ca

Section: CardiologyMar 3, 2026

Integrating Serum Metabolomics and Polygenic Risk Scores Redefines 5-Year Atrial Fibrillation Prediction

Integrating Serum Metabolomics and Polygenic Risk Scores Redefines 5-Year Atrial Fibrillation Prediction

A massive UK Biobank study demonstrates that combining serum metabolomics with polygenic risk scores and clinical data significantly improves the prediction of incident atrial fibrillation, identifying key metabolic markers like linoleic ac

Section: CardiologyMar 2, 2026

Preoperative ctDNA Detects Occult Nodal Metastasis and Predicts Recurrence in Early-Stage Esophageal Squamous Cell Carcinoma

Preoperative ctDNA Detects Occult Nodal Metastasis and Predicts Recurrence in Early-Stage Esophageal Squamous Cell Carcinoma

A multi-center study demonstrates that preoperative ctDNA detection significantly outperforms traditional clinical criteria in predicting nodal upstaging and survival outcomes for patients with clinical stage I/II ESCC, potentially redefini

Section: General SurgeryFeb 20, 2026

Low Baseline PSA Predicts Exceptional Long-Term Safety: A 20-Year Paradigm Shift in Prostate Cancer Screening

Low Baseline PSA Predicts Exceptional Long-Term Safety: A 20-Year Paradigm Shift in Prostate Cancer Screening

A 20-year cohort study shows that baseline PSA levels in men aged 45-70 are highly predictive of long-term prostate cancer risk, with PSA

Section: newsFeb 10, 2026

Time-Varying Risks in Colorectal Adenoma Recurrence: Why Histology and Demographics Demand a Personalized Surveillance Calendar

Time-Varying Risks in Colorectal Adenoma Recurrence: Why Histology and Demographics Demand a Personalized Surveillance Calendar

A massive cohort study reveals that colorectal adenoma recurrence risk is not static; high-grade dysplasia, villous histology, obesity, and sex-based factors exhibit distinct time-varying patterns, necessitating a shift toward personalized,

Section: GastroenterologyFeb 5, 2026

Beyond the Binary: A New 4-Stage Stratification System Revolutionizes Cochlear Implant Candidacy Assessment

Beyond the Binary: A New 4-Stage Stratification System Revolutionizes Cochlear Implant Candidacy Assessment

Researchers have developed a 4-level classification system using routine audiometric data to estimate cochlear implant candidacy likelihood. This tool moves beyond traditional binary screening, providing a probability gradient that enhances

Section: newsJan 27, 2026

Precision Medicine in Atrial Fibrillation: Biomarker-Based ABC-AF Risk Scores Fail to Outperform Standard Care

Precision Medicine in Atrial Fibrillation: Biomarker-Based ABC-AF Risk Scores Fail to Outperform Standard Care

A large-scale registry-based RCT reveals that tailoring atrial fibrillation treatment using the biomarker-driven ABC-AF risk score does not significantly reduce stroke or death compared to current standard guideline-based care, highlighting

Section: CardiologyJan 18, 2026