Early-life respiratory infections show a dose-dependent increase in atopic dermatitis (AD) risk during childhood across two independent birth cohorts.
Associations persist after adjustment for known AD risk factors including filaggrin (FLG) gene mutations and systemic antibiotic treatments.
Respiratory infections, rather than other infection subtypes, principally drive the increased AD risk, highlighting a potential mechanistic link.
Findings underscore the exposome’s role in AD pathogenesis and reveal windows for potential preventive strategies targeting early respiratory infection burden.
Background
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