Early Respiratory Infection Burden and Atopic Dermatitis in Childhood: Insights from Prospective Birth Cohorts
Highlights
- Early-life respiratory infections show a dose-dependent increase in atopic dermatitis (AD) risk during childhood across two independent birth cohorts.
- Associations persist after adjustment for known AD risk factors including filaggrin (FLG) gene mutations and systemic antibiotic treatments.
- Respiratory infections, rather than other infection subtypes, principally drive the increased AD risk, highlighting a potential mechanistic link.
- Findings underscore the exposome’s role in AD pathogenesis and reveal windows for potential preventive strategies targeting early respiratory infection burden.
Background
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This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.