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Trastuzumab deruxtecan combined with pertuzumab significantly improves progression-free survival over standard therapy in first-line HER2-positive metastatic breast cancer, offering enhanced response duration with manageable safety.
A secondary analysis of the SUMMIT trial shows that brief behavioral activation therapy significantly reduces suicide ideation in perinatal women, regardless of clinician type or treatment modality, highlighting a scalable approach for suic
This study nested within the E-MOTIVE trial reveals that using a lower blood loss threshold combined with clinical signs leads to earlier postpartum haemorrhage diagnosis and intervention, potentially reducing adverse outcomes in diverse Af
This review discusses a phase 3 trial demonstrating that sacituzumab govitecan improves progression-free survival in untreated, advanced triple-negative breast cancer patients not eligible for PD-1/PD-L1 inhibitors.
Roche announces positive phase 3 results of giredestrant plus everolimus, significantly reducing disease progression risk in ER+ HER2- advanced breast cancer patients post CDK4/6 inhibitor exposure, with favorable safety and promising survi
Bayer’s Lynkuet (elinzanetant), a first-in-class dual neurokinin 1 and 3 receptor antagonist, has received FDA approval for treatment of moderate to severe menopausal vasomotor symptoms, demonstrating sustained efficacy and favorable
The CIRCUIT trial demonstrates that closed-loop insulin delivery significantly improves glycemic control during pregnancy in type 1 diabetes, increasing time in pregnancy-specific glucose range and reducing hypoglycemia risks relative to st
A novel, evidence-based counseling tool was developed to guide patients in safely resuming sexual activity after pelvic reconstructive surgery. The tool integrates patient perspectives and expert input, addressing safety, discomfort, and re
This article reviews 12 evidence-backed strategies to enhance sustainability in gynecologic surgery by minimizing single-use disposables and reducing carbon emissions in the operating room.
A comprehensive bibliometric analysis of the 100 most-cited articles in premature ovarian insufficiency reveals key research trends, leading contributors, and emerging scientific directions in genetics, cardiovascular disease, and immunolog
This clinical trial prospectively evaluates how a 12-gene expression assay (DCIS score) guides postoperative radiotherapy decisions after breast-conserving surgery in ductal carcinoma in situ, showing tailored radiotherapy use may reduce ip
A UK cohort study reveals that adolescent dysmenorrhoea increases the risk of chronic pain in adulthood, highlighting the need for early identification and management.
This study highlights the prognostic significance of tumor Ki-67 changes during neoadjuvant treatment, offering potential for improved risk stratification and personalized therapy in breast cancer patients.
This study finds no significant benefit of the Circle of Security-Parenting intervention added to usual care for improving mental health and bonding among new parents in NHS settings.
This study offers insights into the prevalence, characteristics, and long-term survival of breast cancer patients eligible for adjuvant CDK4/6 inhibitors, highlighting real-world outcomes compared to clinical trial populations.
This comprehensive review examines the recent Finnish study highlighting the complex relationship between hyperemesis gravidarum and depression, emphasizing clinical implications for integrated mental health screening during reproductive ca
Selenium supplementation at 200 µg/d may reduce fasting plasma glucose and newborn hyperbilirubinemia risk in gestational diabetes without significantly altering lipid profiles, highlighting potential but limited benefits requiring further
This article reviews current evidence from a Cochrane systematic review on vaginal laser therapy for stress urinary incontinence in women, highlighting uncertain efficacy and safety profiles compared to sham and other treatments.
A large randomized clinical trial found that myo-inositol supplementation during pregnancy in individuals with PCOS did not significantly reduce rates of gestational diabetes, preeclampsia, or preterm birth compared to placebo.
This cohort study reveals that women with screen-detected breast cancer who missed the immediate prior mammography screening have larger tumors, more advanced disease, and worse breast cancer-specific survival, suggesting delayed detection
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